Detailed information of TA system TA204549

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1990913..1991689
• Replicon: chromosome
• Accession: NZ_CP076027
• Organism: Staphylococcus sp. MZ7

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: KI234_RS09690
• Protein ID: WP_000031108.1
• Coordinates: 1990913..1991065 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KI234_RS09695
• Protein ID: WP_001251224.1
• Coordinates: 1991090..1991689 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI234_RS09675 (KI234_09675)	1987050..1987871	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
KI234_RS09680 (KI234_09680)	1988334..1989719	-	1386	WP_000116229.1	class II fumarate hydratase	-
KI234_RS09685 (KI234_09685)	1989915..1990310	-	396	WP_000901023.1	hypothetical protein	-
KI234_RS09690 (KI234_09690)	1990913..1991065	-	153	WP_000031108.1	SAS053 family protein	Toxin
KI234_RS09695 (KI234_09695)	1991090..1991689	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
KI234_RS09700 (KI234_09700)	1991848..1992318	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KI234_RS09705 (KI234_09705)	1992323..1993450	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
KI234_RS09710 (KI234_09710)	1993601..1994323	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
KI234_RS09715 (KI234_09715)	1994316..1995773	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T204549 WP_000031108.1 NZ_CP076027:c1991065-1990913 [Staphylococcus sp. MZ7]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T204549 NZ_CP100764:c941068-940694 [Serratia plymuthica]
ATGGATAAGCACCAAGTAAAACAGCTGATATGGATAGCAAGCAGTAAAAAAGACCTGCTTTCGCTGCCTGAAGAAATTAT
TAAATCAATGGGTTATACCCTACATTGGGTTCAGGCGGGATTAACGCCACCCGGAGTGAACCCCTTAAAGGGATTTCTGG
GTGCTGGCGTATTGGAAAAGGTTGAGGATTTTGACGGTAACACCTACCGGGCAGTTTATACCGTGCGGTTCGAAGACACT
GTATTTGTGCTCCACTGCTTTCAGAAAAAATCCAAAACAGGAATTTCAACGCCAAAGGCGGACATTGAATTCATCAAGTC
TCGCCTGAGCAAAGCCAAACAGATTTACGAGGACATGAAAAATGGCAAAATATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT204549 WP_001251224.1 NZ_CP076027:c1991689-1991090 [Staphylococcus sp. MZ7]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT204549 NZ_CP100764:c940707-940378 [Serratia plymuthica]
ATGGCAAAATATGACGAAAATGATTTTGAGATCGGTTCGGACAACATTTTTGCTGATTTAAAACTGCCTGATGCAGAAAA
CCTTAAACTAAAGGCCGATCTCGCCATCAAAATTATCAATACAATTCAACAGCTAGGACTCAACCAAGTAGAAGCGGGCA
AACGAATGAACCTGCCACAGGCACGAGTTTCCGCGTTGTATAACGGCAAATTTTTCAATATGTCAGAGCAAAAGCTGATG
ATCTGCCTCAACCGACTCGGTTACGACATAGAAATTATCGTCAAACCCAGCCAGAACACCGTCGGCCAGCGTACCCTTTC
AGTGACGTAA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4