204539

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2141028..2141542 Replicon chromosome
Accession NZ_CP076026
Organism Staphylococcus sp. MZ3

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KI230_RS10465 Protein ID WP_000581792.1
Coordinates 2141028..2141237 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KI230_RS10470 Protein ID WP_000138932.1
Coordinates 2141249..2141542 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI230_RS10445 (KI230_10445) 2136536..2137894 - 1359 WP_045177762.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KI230_RS10450 (KI230_10450) 2137909..2138979 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
KI230_RS10455 (KI230_10455) 2139297..2140499 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KI230_RS10460 (KI230_10460) 2140763..2140900 - 138 WP_000828354.1 Lmo0850 family protein -
KI230_RS10465 (KI230_10465) 2141028..2141237 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KI230_RS10470 (KI230_10470) 2141249..2141542 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KI230_RS10475 (KI230_10475) 2141708..2143192 + 1485 WP_000571549.1 cardiolipin synthase -
KI230_RS10480 (KI230_10480) 2143220..2143867 + 648 WP_001187630.1 HD domain-containing protein -
KI230_RS10485 (KI230_10485) 2144333..2145205 - 873 WP_000725802.1 membrane protein insertase YidC -
KI230_RS10490 (KI230_10490) 2145291..2145932 - 642 WP_000483164.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T204539 WP_000581792.1 NZ_CP076026:c2141237-2141028 [Staphylococcus sp. MZ3]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T204539 NZ_CP100755:30499-30753 [Alcaligenes sp. NLF5-7]
ATGAAAATCATCTCGTTTTCAGAAGCGCGCAACAGCTTGAAAGCTGTACTGGATAGCGTAGTCGATGACGCCAGCACCAC
CATCATCACGCGTCGTGATGCGGAAGACGCTGTAGTCATGTCACTCGATTACTACAACAGCTTGATGGAAACCGTCCATC
TGCTGCGCTCCCCCGCTAATGCGGAACACCTGAGCCGCTCTATCGAACAATATCGTGCTGGCAAAGCCATGCCACGCGAG
CTGAGCGATGACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT204539 WP_000138932.1 NZ_CP076026:c2141542-2141249 [Staphylococcus sp. MZ3]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT204539 NZ_CP100755:30746-31009 [Alcaligenes sp. NLF5-7]
ATGACTGACCGTTTGTTATGCTGGACTGACGCTGCCTGGATTGACTATGTGTATTGGCAAGGCCAGGACCGCAAGACATT
GAAGCGTATCAACAGACTGATAGAGGAAGTACGACGTGCGCCATTCGATGGCATAGGCAAACCTGAAGCGCTTAAAGAAA
ATCTGTCCGGCTTTTGGTCAAGACGCATTGATGACACGAATCGCCTGGTCTATGCCGTAGACAAGGCAAGCATCACCATC
ATTTCTTGTCGTTATCATTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References