Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1967291..1968067 Replicon chromosome
Accession NZ_CP076026
Organism Staphylococcus sp. MZ3

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag KI230_RS09480 Protein ID WP_000031108.1
Coordinates 1967291..1967443 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag KI230_RS09485 Protein ID WP_001251224.1
Coordinates 1967468..1968067 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI230_RS09465 (KI230_09465) 1963428..1964249 + 822 WP_000669376.1 RluA family pseudouridine synthase -
KI230_RS09470 (KI230_09470) 1964712..1966097 - 1386 WP_000116229.1 class II fumarate hydratase -
KI230_RS09475 (KI230_09475) 1966293..1966688 - 396 WP_000901023.1 hypothetical protein -
KI230_RS09480 (KI230_09480) 1967291..1967443 - 153 WP_000031108.1 SAS053 family protein Toxin
KI230_RS09485 (KI230_09485) 1967468..1968067 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
KI230_RS09490 (KI230_09490) 1968226..1968696 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KI230_RS09495 (KI230_09495) 1968701..1969828 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
KI230_RS09500 (KI230_09500) 1969979..1970701 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
KI230_RS09505 (KI230_09505) 1970694..1972151 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T204537 WP_000031108.1 NZ_CP076026:c1967443-1967291 [Staphylococcus sp. MZ3]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T204537 NZ_CP100753:3672677-3672880 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCAGATCATCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT204537 WP_001251224.1 NZ_CP076026:c1968067-1967468 [Staphylococcus sp. MZ3]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT204537 NZ_CP100753:3672259-3672627 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTATGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References