Detailed information of TA system TA204533

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 847415..847892
• Replicon: chromosome
• Accession: NZ_CP076026
• Organism: Staphylococcus sp. MZ3

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: KI230_RS03970
• Protein ID: WP_000052076.1
• Coordinates: 847415..847603 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: KI230_RS03975
• Protein ID: WP_001059690.1
• Coordinates: 847632..847892 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI230_RS03940 (KI230_03940)	843457..843927	+	471	WP_000824472.1	hypothetical protein	-
KI230_RS03945 (KI230_03945)	844268..844953	+	686	Protein_772	thermonuclease family protein	-
KI230_RS03950 (KI230_03950)	845310..845510	+	201	WP_001059082.1	cold-shock protein	-
KI230_RS03955 (KI230_03955)	846006..846224	-	219	WP_000005886.1	hypothetical protein	-
KI230_RS03960 (KI230_03960)	846286..846570	-	285	WP_001004401.1	hypothetical protein	-
KI230_RS03965 (KI230_03965)	846658..847227	-	570	WP_045178121.1	lipoprotein N-acylation protein LnsA	-
KI230_RS03970 (KI230_03970)	847415..847603	-	189	WP_000052076.1	hypothetical protein	Toxin
KI230_RS03975 (KI230_03975)	847632..847892	-	261	WP_001059690.1	hypothetical protein	Antitoxin
KI230_RS03980 (KI230_03980)	848233..848436	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
KI230_RS03985 (KI230_03985)	848433..848669	-	237	WP_000368687.1	hypothetical protein	-
KI230_RS03990 (KI230_03990)	848894..849475	+	582	WP_001140697.1	histidine phosphatase family protein	-
KI230_RS03995 (KI230_03995)	849548..850165	-	618	WP_000255553.1	LysE/ArgO family amino acid transporter	-
KI230_RS04000 (KI230_04000)	850320..850814	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
KI230_RS04005 (KI230_04005)	851213..851635	-	423	WP_000974460.1	organic hydroperoxide resistance protein	-
KI230_RS04010 (KI230_04010)	851783..852499	+	717	WP_000150017.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T204533 WP_000052076.1 NZ_CP076026:c847603-847415 [Staphylococcus sp. MZ3]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T204533 NZ_CP100753:c1684970-1684767 [Serratia marcescens]
GTGAAGAGTTCAGAACTGATTGCGCTGCTGGAAAGCCACGGTTGGGTATTGCGGCGGGTAAAAGGCAGCCACCATCAATT
CAAACATCCCGATTTTGCGCTGATCATCACCGTGCCGCATCCAAAGAAAGATCTCAAGCTGGGCACGCTGCGGCAGATAC
TTAAAGACGCGGGGTTAAGTGCGCTTCACATCGCCACGCGTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT204533 WP_001059690.1 NZ_CP076026:c847892-847632 [Staphylococcus sp. MZ3]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT204533 NZ_CP100753:c1684755-1684342 [Serratia marcescens]
ATGTTTTATCCCGCTTATATCCATACAGAATCAAACGGCAGCGCCAGCGGTTTCTTTCCCGACGTCCCTGGCTGCTACTT
CGCCGGCACCAGCCTGGACGACGCTTTTGCCGATGCCCAAAGCGCACTGGATGCGCACTTTGAGTTGTTGAGCGAAGACA
ATCAACCGCTACCGCGCCCGCATGCCGTCGCAGCCCATCTTGCCAAAGATGCGGGATCCTTCGAGGGAGGACAATGGCTA
TTGGTCGCTATCAATATGGATAAATTTGACGGCCGAGCCGAACGGATTAACATCACGTTGCCCCATCGCCTGTTAAGTCG
CATTGACTCTCTGGTTCGGCAACATCCGGGATACGGCAGCCGCAGCGGATTTCTCGCCGCCGCCGCGCGCAATGAATTGT
TGAAAGCAGAGTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56