Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2926214..2926928 Replicon chromosome
Accession NC_002755
Organism Mycobacterium tuberculosis CDC1551

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag MT_RS13675 Protein ID WP_003413460.1
Coordinates 2926488..2926928 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag MT_RS13670 Protein ID WP_003413456.1
Coordinates 2926214..2926501 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT_RS13635 2921636..2921881 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
MT_RS13640 2921878..2922282 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
MT_RS13645 2922499..2923119 + 621 WP_003413441.1 DUF4178 domain-containing protein -
MT_RS13650 2923130..2923624 + 495 WP_003413444.1 DUF2617 family protein -
MT_RS13655 2923621..2924052 + 432 WP_003899390.1 DUF4247 domain-containing protein -
MT_RS13660 2924077..2924535 + 459 WP_003413451.1 DUF350 domain-containing protein -
MT_RS13665 2924532..2926103 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
MT_RS13670 2926214..2926501 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
MT_RS13675 2926488..2926928 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
MT_RS13680 2926949..2927704 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
MT_RS13685 2927837..2928433 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
MT_RS13690 2928441..2929286 - 846 WP_003413466.1 acyl-CoA thioesterase II -
MT_RS13695 2929315..2930214 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
MT_RS13700 2930342..2931016 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T20453 WP_003413460.1 NC_002755:2926488-2926928 [Mycobacterium tuberculosis CDC1551]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T20453 NC_002755:2926488-2926928 [Mycobacterium tuberculosis CDC1551]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT20453 WP_003413456.1 NC_002755:2926214-2926501 [Mycobacterium tuberculosis CDC1551]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT20453 NC_002755:2926214-2926501 [Mycobacterium tuberculosis CDC1551]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References