Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2114201..2114715 Replicon chromosome
Accession NZ_CP076025
Organism Staphylococcus sp. MZ1

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KI229_RS10345 Protein ID WP_000581792.1
Coordinates 2114201..2114410 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KI229_RS10350 Protein ID WP_000138932.1
Coordinates 2114422..2114715 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI229_RS10325 (KI229_10325) 2109709..2111067 - 1359 WP_045177762.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KI229_RS10330 (KI229_10330) 2111082..2112152 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
KI229_RS10335 (KI229_10335) 2112470..2113672 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KI229_RS10340 (KI229_10340) 2113936..2114073 - 138 WP_000828354.1 Lmo0850 family protein -
KI229_RS10345 (KI229_10345) 2114201..2114410 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KI229_RS10350 (KI229_10350) 2114422..2114715 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KI229_RS10355 (KI229_10355) 2114881..2116365 + 1485 WP_000571549.1 cardiolipin synthase -
KI229_RS10360 (KI229_10360) 2116393..2117040 + 648 WP_001187630.1 HD domain-containing protein -
KI229_RS10365 (KI229_10365) 2117506..2118378 - 873 WP_000725802.1 membrane protein insertase YidC -
KI229_RS10370 (KI229_10370) 2118464..2119105 - 642 WP_000483164.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T204528 WP_000581792.1 NZ_CP076025:c2114410-2114201 [Staphylococcus sp. MZ1]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T204528 NZ_CP100753:c214170-213880 [Serratia marcescens]
ATGATTAAATCTTTCCGCGATCGCTATCTGGAGCAGTTCTATCTGGAAGGCAAACGCAGCCGTCTGATCCCCGGCGTGCT
CGAGCGGCAGTTGGCCAGAAAGCTCGATATATTGGCCGCCGCGCAGCAAGAGCGTGATTTGCATCACCCCACGGGTAACT
ATTACAAGCGGCTATCCGGGCCATTTCAGGGATGGTCAAGTCTGCGCGTCAATATGCACTGGCGGCTGATGTTCCAGTGG
CGGCATGATGCCGCTGAAAAAATTTACCTCGATCCTCACCAAGATACCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT204528 WP_000138932.1 NZ_CP076025:c2114715-2114422 [Staphylococcus sp. MZ1]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT204528 NZ_CP100753:c213865-213542 [Serratia marcescens]
ATGTTGGAAACCACGACTCGCGAACCCACCACGGTGGGGGAAGTGCTGCAGGAAGAGTATTTAACGCCGTTGGGCATCGG
CCAGGAAGAACTGGCGAAGGTACTGGGCGTCACCCGTGCCACTGTTAACCGCCTGTGCAACGGGCATCGACGCATGAGCG
TTGCCGAGGCCAACCTGTTTGCCGACCTGTTCGAAACGACCGCCGACTTTTGGCTAAACCTGCAGGCGGCACACGATCGC
TGGGAAGCCAGACAGGCCGATGCGCAACGTGTGCGGCTGCGGCCAATCAAAGAAATACTGGGACGCAATATCACTCATGC
ATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References