Detailed information of TA system TA204526

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1940462..1941238
• Replicon: chromosome
• Accession: NZ_CP076025
• Organism: Staphylococcus sp. MZ1

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: KI229_RS09360
• Protein ID: WP_000031108.1
• Coordinates: 1940462..1940614 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KI229_RS09365
• Protein ID: WP_001251224.1
• Coordinates: 1940639..1941238 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI229_RS09345 (KI229_09345)	1936599..1937420	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
KI229_RS09350 (KI229_09350)	1937883..1939268	-	1386	WP_000116229.1	class II fumarate hydratase	-
KI229_RS09355 (KI229_09355)	1939464..1939859	-	396	WP_000901023.1	hypothetical protein	-
KI229_RS09360 (KI229_09360)	1940462..1940614	-	153	WP_000031108.1	SAS053 family protein	Toxin
KI229_RS09365 (KI229_09365)	1940639..1941238	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
KI229_RS09370 (KI229_09370)	1941397..1941867	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KI229_RS09375 (KI229_09375)	1941872..1942999	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
KI229_RS09380 (KI229_09380)	1943150..1943872	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
KI229_RS09385 (KI229_09385)	1943865..1945322	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T204526 WP_000031108.1 NZ_CP076025:c1940614-1940462 [Staphylococcus sp. MZ1]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T204526 NZ_CP100752:c1387636-1386890 [Bacillus halotolerans]
ATGCTTTTATTCTTTCAAATCATGGTCTGGTGCACTATGGCCGCTTTAGGCTTATACGTATACGCCACATGGCGGTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGAAAAACATGGTATTTGCTGTTTGTTTTGGGCGCCATGATATACTGGA
CATATGATCCCTCTTCCCTGTTCACAAACTGGGAACGGTATGTCATTGTCGCTGTCAGCTTTGCTTTAATTGACGCTTTT
ATCTTTTTGAGCGCTTATGTGAAAAAACTGGCCGGCAGTGAACTGGAAACAGACACAAGAGAAATTCTCGAAGAAAACAA
CGAAATGCTCCACATGTATCTCGATCGGCTGAAAACATACCAATATCTATTGAAAAATGAACCGATTCATGTTTATTATG
GAAGTATAGAAGCATATGCTGAAGGAATTGATAAACTGCTGAAAACCTATGCTGATAAAATGAATCTGACGGCCAGCCTT
TGTCACTATTCGACACAGTCTGATAAAGACCGGTTAACCGAGCACATGGAGGATCCCGCTGACGTGCAAACGAGGCTGGA
TCGAAAGGATGTCTATTACGACCAGTATGGAAAAGTAGTGCTCATTCCCTTTACAATCGAGACACAGAGCTATGTCATCA
AACTGACGTCTGACAGTATTGTAACGGAATTTGATTATTTGCTATTCACATCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT204526 WP_001251224.1 NZ_CP076025:c1941238-1940639 [Staphylococcus sp. MZ1]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT204526 NZ_CP100752:c1386890-1386720 [Bacillus halotolerans]
ATGGAAAACGCGTTTCAAAACGGATGCCATCCGCGGGCAAAGAAACCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCACACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGATGAGTATAAACGAA
AAAAAGCATGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4