Detailed information of TA system TA204522

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 834735..835212
• Replicon: chromosome
• Accession: NZ_CP076025
• Organism: Staphylococcus sp. MZ1

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: KI229_RS03935
• Protein ID: WP_000052076.1
• Coordinates: 834735..834923 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: KI229_RS03940
• Protein ID: WP_001059690.1
• Coordinates: 834952..835212 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI229_RS03905 (KI229_03905)	830777..831247	+	471	WP_000824472.1	hypothetical protein	-
KI229_RS03910 (KI229_03910)	831588..832273	+	686	Protein_766	thermonuclease family protein	-
KI229_RS03915 (KI229_03915)	832630..832830	+	201	WP_001059082.1	cold-shock protein	-
KI229_RS03920 (KI229_03920)	833326..833544	-	219	WP_000005886.1	hypothetical protein	-
KI229_RS03925 (KI229_03925)	833606..833890	-	285	WP_001004401.1	hypothetical protein	-
KI229_RS03930 (KI229_03930)	833978..834547	-	570	WP_045178121.1	lipoprotein N-acylation protein LnsA	-
KI229_RS03935 (KI229_03935)	834735..834923	-	189	WP_000052076.1	hypothetical protein	Toxin
KI229_RS03940 (KI229_03940)	834952..835212	-	261	WP_001059690.1	hypothetical protein	Antitoxin
KI229_RS03945 (KI229_03945)	835553..835756	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
KI229_RS03950 (KI229_03950)	835753..835989	-	237	WP_000368687.1	hypothetical protein	-
KI229_RS03955 (KI229_03955)	836214..836795	+	582	WP_214958375.1	histidine phosphatase family protein	-
KI229_RS03960 (KI229_03960)	836868..837485	-	618	WP_000255553.1	LysE/ArgO family amino acid transporter	-
KI229_RS03965 (KI229_03965)	837640..838134	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
KI229_RS03970 (KI229_03970)	838533..838955	-	423	WP_000974460.1	organic hydroperoxide resistance protein	-
KI229_RS03975 (KI229_03975)	839103..839819	+	717	WP_000150017.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-74)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T204522 WP_000052076.1 NZ_CP076025:c834923-834735 [Staphylococcus sp. MZ1]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T204522 NZ_CP100747:c4458289-4457978 [Salmonella enterica subsp. enterica serovar Montevideo]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT204522 WP_001059690.1 NZ_CP076025:c835212-834952 [Staphylococcus sp. MZ1]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT204522 NZ_CP100747:c4457977-4457687 [Salmonella enterica subsp. enterica serovar Montevideo]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTAAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGCTCACCGACAGGGCCAGCCAAAGCATTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56