Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 1163026..1163478 Replicon chromosome
Accession NZ_CP076024
Organism Methylobacter sp. S3L5C

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KKZ03_RS05345 Protein ID WP_243220507.1
Coordinates 1163026..1163223 (-) Length 66 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KKZ03_RS05350 Protein ID WP_243220508.1
Coordinates 1163278..1163478 (-) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKZ03_RS05330 (KKZ03_05330) 1159557..1161944 - 2388 WP_243220504.1 DEAD/DEAH box helicase family protein -
KKZ03_RS05335 (KKZ03_05335) 1162056..1162478 - 423 WP_243220505.1 type II toxin-antitoxin system VapC family toxin -
KKZ03_RS05340 (KKZ03_05340) 1162466..1162744 - 279 WP_243220506.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
KKZ03_RS05345 (KKZ03_05345) 1163026..1163223 - 198 WP_243220507.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KKZ03_RS05350 (KKZ03_05350) 1163278..1163478 - 201 WP_243220508.1 ribbon-helix-helix domain-containing protein Antitoxin
KKZ03_RS05355 (KKZ03_05360) 1164595..1164786 - 192 WP_243220509.1 hypothetical protein -
KKZ03_RS05360 (KKZ03_05365) 1164796..1165095 - 300 WP_256452006.1 transposase -
KKZ03_RS05365 (KKZ03_05370) 1165129..1165482 - 354 WP_243220511.1 IS66 family transposase zinc-finger binding domain-containing protein -
KKZ03_RS21775 (KKZ03_05375) 1166184..1166318 - 135 WP_256451998.1 transposase -
KKZ03_RS05375 1166364..1166726 - 363 WP_243220512.1 transposase family protein -
KKZ03_RS05380 1166698..1167201 - 504 WP_243220513.1 transposase family protein -
KKZ03_RS05385 (KKZ03_05385) 1167672..1168031 + 360 WP_243220514.1 ATP synthase subunit I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-58)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7575.80 Da        Isoelectric Point: 8.6604

>T204520 WP_243220507.1 NZ_CP076024:c1163223-1163026 [Methylobacter sp. S3L5C]
MKIVWTEPARQDLRDIFTYIAENNPKTARKLLNDIKERTVLLQDNPLIGRLGRIEDTRELVLIGT

Download         Length: 198 bp

>T204520 NZ_CP100747:c4041892-4041608 [Salmonella enterica subsp. enterica serovar Montevideo]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7430.51 Da        Isoelectric Point: 10.0561

>AT204520 WP_243220508.1 NZ_CP076024:c1163478-1163278 [Methylobacter sp. S3L5C]
MATEAFSIRVETEIIHKLDNLAGSLDRSRNYLVNQAIKAYLQANASACAKITQRYSGSKSWRIRCP

Download         Length: 201 bp

>AT204520 NZ_CP100747:c4042124-4041882 [Salmonella enterica subsp. enterica serovar Montevideo]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAGGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAGGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References