Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2865872..2866509 Replicon chromosome
Accession NC_002755
Organism Mycobacterium tuberculosis CDC1551

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag MT_RS13410 Protein ID WP_003413180.1
Coordinates 2865872..2866267 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag MT_RS13415 Protein ID WP_003413183.1
Coordinates 2866264..2866509 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT_RS13370 2861957..2862616 + 660 WP_003900846.1 LppA family lipoprotein -
MT_RS13375 2862613..2863272 + 660 WP_003900847.1 hypothetical protein -
MT_RS13380 2863269..2863931 + 663 WP_003900848.1 hypothetical protein -
MT_RS13385 2863928..2864206 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
MT_RS13390 2864299..2864712 + 414 WP_003413164.1 PIN domain nuclease -
MT_RS13395 2864751..2865008 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein -
MT_RS13400 2865005..2865382 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
MT_RS13405 2865398..2865772 - 375 WP_003413177.1 hypothetical protein -
MT_RS13410 2865872..2866267 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
MT_RS13415 2866264..2866509 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
MT_RS13420 2866920..2867339 - 420 WP_003413190.1 A24 family peptidase -
MT_RS13425 2867351..2868160 - 810 WP_003413193.1 shikimate dehydrogenase -
MT_RS13430 2868157..2869410 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
MT_RS13435 2869403..2869915 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T20452 WP_003413180.1 NC_002755:c2866267-2865872 [Mycobacterium tuberculosis CDC1551]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

>T20452 NC_002755:c2866267-2865872 [Mycobacterium tuberculosis CDC1551]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT20452 WP_003413183.1 NC_002755:c2866509-2866264 [Mycobacterium tuberculosis CDC1551]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp

>AT20452 NC_002755:c2866509-2866264 [Mycobacterium tuberculosis CDC1551]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References