Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-RHH
Location 3282790..3283334 Replicon chromosome
Accession NZ_CP076023
Organism Cellulomonas dongxiuzhuiae strain zg-ZUI157

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KKR89_RS14870 Protein ID WP_208196121.1
Coordinates 3282790..3283095 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KKR89_RS14875 Protein ID WP_208196122.1
Coordinates 3283095..3283334 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKR89_RS14855 (KKR89_14855) 3278081..3279316 + 1236 WP_191782662.1 D-galactonate dehydratase family protein -
KKR89_RS14860 (KKR89_14860) 3279313..3281508 + 2196 WP_208196119.1 alpha-glucuronidase -
KKR89_RS14865 (KKR89_14865) 3281626..3282666 - 1041 WP_208196120.1 aldo/keto reductase -
KKR89_RS14870 (KKR89_14870) 3282790..3283095 - 306 WP_208196121.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KKR89_RS14875 (KKR89_14875) 3283095..3283334 - 240 WP_208196122.1 ribbon-helix-helix domain-containing protein Antitoxin
KKR89_RS14880 (KKR89_14880) 3283445..3285481 - 2037 WP_208196123.1 beta-galactosidase -
KKR89_RS14885 (KKR89_14885) 3285516..3286235 - 720 WP_208196124.1 glycosyl transferase -
KKR89_RS14890 (KKR89_14890) 3286235..3287779 - 1545 WP_208196125.1 xylan 1,4-beta-xylosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-43)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 10850.56 Da        Isoelectric Point: 5.0345

>T204518 WP_208196121.1 NZ_CP076023:c3283095-3282790 [Cellulomonas dongxiuzhuiae]
MRPIHVAELDKARPVLVLTRELVRPHLSSVTVAPITTTVRGLSTEVPLGRANGLDQDCVVSCDNVQTVPASALGRQIGYL
LPDQEARLALAIALAFDLEPE

Download         Length: 306 bp

>T204518 NZ_CP100747:3360145-3360363 [Salmonella enterica subsp. enterica serovar Montevideo]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACAATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8652.80 Da        Isoelectric Point: 4.7640

>AT204518 WP_208196122.1 NZ_CP076023:c3283334-3283095 [Cellulomonas dongxiuzhuiae]
MTIQITVRLDDDLVQAVDALVAEGRARSRAAVVEVALERHLRRELATRDVEILRGDPSGTDLDALAAWSHQLPAPRGLD

Download         Length: 240 bp

>AT204518 NZ_CP100747:3359743-3360117 [Salmonella enterica subsp. enterica serovar Montevideo]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAAC
ATATTGCAACTTTCGCTCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References