Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4845018..4845534 Replicon chromosome
Accession NZ_CP076008
Organism Klebsiella pneumoniae subsp. pneumoniae strain WGR351

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag J4H97_RS23515 Protein ID WP_009486548.1
Coordinates 4845018..4845302 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag J4H97_RS23520 Protein ID WP_002886901.1
Coordinates 4845292..4845534 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4H97_RS23490 (4840435) 4840435..4840698 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
J4H97_RS23495 (4840828) 4840828..4841001 + 174 WP_032433782.1 hypothetical protein -
J4H97_RS23500 (4841004) 4841004..4841747 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
J4H97_RS23505 (4842104) 4842104..4844242 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
J4H97_RS23510 (4844550) 4844550..4845014 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
J4H97_RS23515 (4845018) 4845018..4845302 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4H97_RS23520 (4845292) 4845292..4845534 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J4H97_RS23525 (4845612) 4845612..4847522 - 1911 WP_009486549.1 PRD domain-containing protein -
J4H97_RS23530 (4847545) 4847545..4848699 - 1155 WP_002886900.1 lactonase family protein -
J4H97_RS23535 (4848766) 4848766..4849506 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T204513 WP_009486548.1 NZ_CP076008:c4845302-4845018 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T204513 NZ_CP100745:271260-271541 [Salmonella enterica subsp. enterica serovar Newport]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAGCTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT204513 WP_002886901.1 NZ_CP076008:c4845534-4845292 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT204513 NZ_CP100745:271019-271270 [Salmonella enterica subsp. enterica serovar Newport]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References