Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 24856..25346 Replicon plasmid p2
Accession NZ_CP075899
Organism Exiguobacterium acetylicum strain SI17

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KKI46_RS17165 Protein ID WP_214814065.1
Coordinates 24856..25122 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KKI46_RS17170 Protein ID WP_214813982.1
Coordinates 25122..25346 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKI46_RS17155 (KKI46_17155) 20894..22363 - 1470 WP_214814060.1 class I SAM-dependent DNA methyltransferase -
KKI46_RS17160 (KKI46_17160) 22376..24730 - 2355 WP_214813980.1 DEAD/DEAH box helicase family protein -
KKI46_RS17165 (KKI46_17165) 24856..25122 - 267 WP_214814065.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KKI46_RS17170 (KKI46_17170) 25122..25346 - 225 WP_214813982.1 DUF6290 family protein Antitoxin
KKI46_RS17175 (KKI46_17175) 25578..25913 - 336 WP_214813984.1 YolD-like family protein -
KKI46_RS17180 (KKI46_17180) 26092..27084 - 993 WP_214813986.1 DNA/RNA non-specific endonuclease -
KKI46_RS17185 (KKI46_17185) 27518..27964 + 447 WP_244989040.1 JAB domain-containing protein -
KKI46_RS17190 (KKI46_17190) 28491..28727 - 237 WP_214813988.1 hypothetical protein -
KKI46_RS17195 (KKI46_17195) 28924..29379 - 456 WP_214813989.1 Rrf2 family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..43790 43790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10372.03 Da        Isoelectric Point: 10.3966

>T204495 WP_214814065.1 NZ_CP075899:c25122-24856 [Exiguobacterium acetylicum]
MAYTVEFERGAQKSLKKMDPQQARIIMSWIKKNLVGTDDPRRHGKGLVSNRSGEWRYRIGDYRLIADIQDEKVVILILEI
GHRRDIYK

Download         Length: 267 bp

>T204495 NZ_CP100739:c4143640-4143356 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8613.79 Da        Isoelectric Point: 4.5127

>AT204495 WP_214813982.1 NZ_CP075899:c25346-25122 [Exiguobacterium acetylicum]
MSTISVRLDDQDTRLIKEYAKAKNITISTLVRDAVLDRIEDEIDLQLYHDSMAAHRKKSEAISFEDMMKELDLE

Download         Length: 225 bp

>AT204495 NZ_CP100739:c4143872-4143630 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References