Detailed information of TA system TA204494

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1531319..1531818
• Replicon: chromosome
• Accession: NZ_CP075897
• Organism: Exiguobacterium acetylicum strain SI17

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KKI46_RS08040
• Protein ID: WP_069940639.1
• Coordinates: 1531319..1531597 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KKI46_RS08045
• Protein ID: WP_069940640.1
• Coordinates: 1531594..1531818 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KKI46_RS08020 (KKI46_08020)	1526787..1527113	+	327	WP_071908772.1	four-helix bundle copper-binding protein	-
KKI46_RS08025 (KKI46_08025)	1527433..1528113	+	681	WP_047394277.1	response regulator transcription factor	-
KKI46_RS08030 (KKI46_08030)	1528151..1528654	-	504	WP_029343432.1	PCYCGC motif-containing (lipo)protein	-
KKI46_RS08035 (KKI46_08035)	1529087..1531093	+	2007	WP_069940638.1	heavy metal translocating P-type ATPase	-
KKI46_RS08040 (KKI46_08040)	1531319..1531597	-	279	WP_069940639.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KKI46_RS08045 (KKI46_08045)	1531594..1531818	-	225	WP_069940640.1	DUF6290 family protein	Antitoxin
KKI46_RS08050 (KKI46_08050)	1532039..1532374	-	336	WP_069940641.1	YolD-like family protein	-
KKI46_RS08055 (KKI46_08055)	1532553..1533038	-	486	Protein_1534	hypothetical protein	-
KKI46_RS17770	1532961..1533221	+	261	WP_069940642.1	hypothetical protein	-
KKI46_RS08060 (KKI46_08060)	1533432..1533752	+	321	WP_069940643.1	hypothetical protein	-
KKI46_RS08065 (KKI46_08065)	1533756..1534046	+	291	WP_069940644.1	addiction module toxin RelE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-88)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10794.38 Da
• Isoelectric Point: 10.1915

>T204494 WP_069940639.1 NZ_CP075897:c1531597-1531319 [Exiguobacterium acetylicum]
MTAYTVEFERGAQKSLKKMDPQQARIIMSWIKNNLVGTDDPRRHGRGLVSNRSGEWRYRIGDYRLIADIQDEKVVILILE
IGHRRDIYKYGS

Nucleotide

• Length: 279 bp

>T204494 NZ_CP100739:c4049671-4049384 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8541.73 Da
• Isoelectric Point: 4.6290

>AT204494 WP_069940640.1 NZ_CP075897:c1531818-1531594 [Exiguobacterium acetylicum]
MSTISVRLDDQDTRLIKEYAKAKNITISTLVRDAVLDRIEDEIDLQLYHDSMAAHRKKSEAISFGDMMKELDLE

Nucleotide

• Length: 225 bp

>AT204494 NZ_CP100739:c4049397-4049095 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG