Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1511852..1512342 Replicon chromosome
Accession NZ_CP075897
Organism Exiguobacterium acetylicum strain SI17

Toxin (Protein)


Gene name relE Uniprot ID A0A0V8GBT6
Locus tag KKI46_RS07940 Protein ID WP_058266059.1
Coordinates 1511852..1512121 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A031ILR5
Locus tag KKI46_RS07945 Protein ID WP_026829710.1
Coordinates 1512118..1512342 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKI46_RS07920 (KKI46_07920) 1506871..1507173 + 303 WP_064300933.1 DUF2089 family protein -
KKI46_RS07925 (KKI46_07925) 1507170..1507454 + 285 WP_050677872.1 hypothetical protein -
KKI46_RS07930 (KKI46_07930) 1507570..1510791 - 3222 WP_214813789.1 ABC transporter permease -
KKI46_RS07935 (KKI46_07935) 1510784..1511479 - 696 WP_069940629.1 ABC transporter ATP-binding protein -
KKI46_RS07940 (KKI46_07940) 1511852..1512121 - 270 WP_058266059.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KKI46_RS07945 (KKI46_07945) 1512118..1512342 - 225 WP_026829710.1 DUF6290 family protein Antitoxin
KKI46_RS07950 (KKI46_07950) 1512540..1513631 - 1092 WP_069940630.1 hypothetical protein -
KKI46_RS07960 (KKI46_07960) 1514307..1514639 + 333 WP_083254799.1 metalloregulator ArsR/SmtB family transcription factor -
KKI46_RS07965 (KKI46_07965) 1514642..1516180 + 1539 WP_083254800.1 cation transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-88)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10501.14 Da        Isoelectric Point: 10.4460

>T204493 WP_058266059.1 NZ_CP075897:c1512121-1511852 [Exiguobacterium acetylicum]
MTAYTVEFERGAQKSLKKMDPQQARIIMSWIKKNLVGTDDPRRHGRGLVSNRSGEWRYRIGDYRLIADIQDEKVVILILE
IGHRRDIYK

Download         Length: 270 bp

>T204493 NZ_CP100739:3637592-3637867 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8599.76 Da        Isoelectric Point: 4.5010

>AT204493 WP_026829710.1 NZ_CP075897:c1512342-1512118 [Exiguobacterium acetylicum]
MSTISVRLDDQDTRLIKEYAKAKNITISTLVRDAVLDRIEDEIDLQLYHDSMAAHRKKSEAISFDDMMKELDLE

Download         Length: 225 bp

>AT204493 NZ_CP100739:c3637857-3637435 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V8GBT6

Antitoxin

Source ID Structure
AlphaFold DB A0A031ILR5

References