Detailed information of TA system TA204492

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 3154100..3154668
• Replicon: chromosome
• Accession: NZ_CP075896
• Organism: Streptomyces sp. MG62

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KJK29_RS13835
• Protein ID: WP_215119363.1
• Coordinates: 3154387..3154668 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KJK29_RS13830
• Protein ID: WP_251057782.1
• Coordinates: 3154100..3154381 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJK29_RS13805 (KJK29_13805)	3149393..3150166	+	774	WP_215119357.1	SDR family oxidoreductase	-
KJK29_RS13810 (KJK29_13810)	3150286..3150993	+	708	WP_215119358.1	ester cyclase	-
KJK29_RS13815 (KJK29_13815)	3151814..3152107	-	294	WP_215119360.1	hypothetical protein	-
KJK29_RS13820 (KJK29_13820)	3152443..3153333	+	891	WP_215119361.1	hypothetical protein	-
KJK29_RS13825 (KJK29_13825)	3153417..3154052	+	636	WP_251057781.1	hypothetical protein	-
KJK29_RS13830 (KJK29_13830)	3154100..3154381	+	282	WP_251057782.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KJK29_RS13835 (KJK29_13835)	3154387..3154668	+	282	WP_215119363.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KJK29_RS38805	3154825..3155328	+	504	Protein_2761	DUF2791 family P-loop domain-containing protein	-
KJK29_RS38810	3155342..3156385	-	1044	WP_251057783.1	hypothetical protein	-
KJK29_RS13845 (KJK29_13845)	3156526..3158151	-	1626	WP_215119365.1	chaperonin GroEL	-
KJK29_RS13850 (KJK29_13850)	3158273..3158581	-	309	WP_003974211.1	co-chaperone GroES	-
KJK29_RS13855 (KJK29_13855)	3158927..3159658	-	732	WP_251057784.1	polysaccharide deacetylase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10885.63 Da
• Isoelectric Point: 10.8148

>T204492 WP_215119363.1 NZ_CP075896:3154387-3154668 [Streptomyces sp. MG62]
MGYVTRFTPHAQRDMLKIPRPDALRILYRLTELQKAMDAGETAAFDVKALRGHNARWRLRVGDYRVVYTVEDGRVVVWVL
TVGNRREVYRQVP

Nucleotide

• Length: 282 bp

>T204492 NZ_CP100739:3406134-3406352 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10603.77 Da
• Isoelectric Point: 4.3741

>AT204492 WP_251057782.1 NZ_CP075896:3154100-3154381 [Streptomyces sp. MG62]
MSEPVVESMAEVRSHLADVIDRARRDKTPTIITRRGKREAVVIDIEEYQRLRQLAEDAEEAWLNRLADEAESEGTDGSVS
LEEMAALLRDQQH

Nucleotide

• Length: 282 bp

>AT204492 NZ_CP100739:3405732-3406106 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA