Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4876205..4876721 Replicon chromosome
Accession NZ_CP075890
Organism Klebsiella pneumoniae strain GR390

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag J4H96_RS24020 Protein ID WP_002886902.1
Coordinates 4876205..4876489 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag J4H96_RS24025 Protein ID WP_002886901.1
Coordinates 4876479..4876721 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4H96_RS23995 (J4H96_23995) 4871689..4871952 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
J4H96_RS24000 (J4H96_24000) 4872082..4872255 + 174 WP_002886906.1 hypothetical protein -
J4H96_RS24005 (J4H96_24005) 4872258..4873001 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
J4H96_RS24010 (J4H96_24010) 4873358..4875496 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
J4H96_RS24015 (J4H96_24015) 4875737..4876201 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
J4H96_RS24020 (J4H96_24020) 4876205..4876489 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4H96_RS24025 (J4H96_24025) 4876479..4876721 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J4H96_RS24030 (J4H96_24030) 4876799..4878709 - 1911 WP_004152270.1 PRD domain-containing protein -
J4H96_RS24035 (J4H96_24035) 4878732..4879886 - 1155 WP_002886900.1 lactonase family protein -
J4H96_RS24040 (J4H96_24040) 4879952..4880692 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T204486 WP_002886902.1 NZ_CP075890:c4876489-4876205 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T204486 NZ_CP100739:365062-365337 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT204486 WP_002886901.1 NZ_CP075890:c4876721-4876479 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT204486 NZ_CP100739:364799-365059 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References