Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870968..871625 Replicon chromosome
Accession NZ_CP075890
Organism Klebsiella pneumoniae strain GR390

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag J4H96_RS04390 Protein ID WP_002916310.1
Coordinates 871215..871625 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag J4H96_RS04385 Protein ID WP_002916312.1
Coordinates 870968..871234 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4H96_RS04360 (J4H96_04360) 866124..867557 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
J4H96_RS04365 (J4H96_04365) 867676..868404 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
J4H96_RS04370 (J4H96_04370) 868454..868765 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
J4H96_RS04375 (J4H96_04375) 868929..869588 + 660 WP_002916317.1 hemolysin III family protein -
J4H96_RS04380 (J4H96_04380) 869739..870722 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
J4H96_RS04385 (J4H96_04385) 870968..871234 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
J4H96_RS04390 (J4H96_04390) 871215..871625 + 411 WP_002916310.1 protein YgfX Toxin
J4H96_RS04395 (J4H96_04395) 871632..872153 - 522 WP_002916308.1 flavodoxin FldB -
J4H96_RS04400 (J4H96_04400) 872254..873150 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
J4H96_RS04405 (J4H96_04405) 873173..873886 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
J4H96_RS04410 (J4H96_04410) 873892..875625 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T204474 WP_002916310.1 NZ_CP075890:871215-871625 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T204474 NZ_CP100736:c2703599-2703496 [Salmonella enterica subsp. enterica serovar Agona]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT204474 WP_002916312.1 NZ_CP075890:870968-871234 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT204474 NZ_CP100736:2703494-2703637 [Salmonella enterica subsp. enterica serovar Agona]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References