Detailed information of TA system TA204470

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazF-pemI/MazF(toxin)
• Location: 8834902..8835537
• Replicon: chromosome
• Accession: NZ_CP075889
• Organism: Paenibacillus agaridevorans strain HCL2020

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: KJW29_RS35125
• Protein ID: WP_087569551.1
• Coordinates: 8835187..8835537 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: -
• Locus tag: KJW29_RS35120
• Protein ID: WP_087569552.1
• Coordinates: 8834902..8835183 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJW29_RS35105	8830703..8831575	+	873	WP_214628143.1	AraC family transcriptional regulator	-
KJW29_RS35110	8831774..8832961	+	1188	WP_214628144.1	outer membrane lipoprotein carrier protein LolA	-
KJW29_RS35115	8833313..8834503	+	1191	WP_214631444.1	alanine racemase	-
KJW29_RS35120	8834902..8835183	+	282	WP_087569552.1	CopG family ribbon-helix-helix protein	Antitoxin
KJW29_RS35125	8835187..8835537	+	351	WP_087569551.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
KJW29_RS35130	8835702..8836484	+	783	WP_214628145.1	SAF domain-containing protein	-
KJW29_RS35135	8836481..8837332	+	852	WP_214628146.1	hypothetical protein	-
KJW29_RS35140	8837329..8838717	+	1389	WP_214628147.1	CpaF/VirB11 family protein	-
KJW29_RS35145	8838776..8839711	+	936	WP_214628148.1	type II secretion system F family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-113)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-45)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12795.76 Da
• Isoelectric Point: 5.1171

>T204470 WP_087569551.1 NZ_CP075889:8835187-8835537 [Paenibacillus agaridevorans]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEMDAATHGFDRDSVVLLEQI
RTIDKQRLTDKITHLDDETMRKVDDALLISVGLIDF

Nucleotide

• Length: 351 bp

>T204470 NZ_CP100736:853551-853964 [Salmonella enterica subsp. enterica serovar Agona]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10748.35 Da
• Isoelectric Point: 7.2046

>AT204470 WP_087569552.1 NZ_CP075889:8834902-8835183 [Paenibacillus agaridevorans]
VANIHNTKRIMISLPDQLLEEVDGIVAKENSNRSEFIRQAMKLYLVERKKRQIRESMQRGYMEMARINLNMASEAFQAEE
EADHTLGRLVSGV

Nucleotide

• Length: 282 bp

>AT204470 NZ_CP100736:853304-853570 [Salmonella enterica subsp. enterica serovar Agona]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA