Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2327969..2328626 Replicon chromosome
Accession NZ_CP075885
Organism Klebsiella quasipneumoniae strain JNQH473

Toxin (Protein)


Gene name cptA Uniprot ID A0A2N4VX63
Locus tag KLH66_RS12465 Protein ID WP_023290968.1
Coordinates 2328216..2328626 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KLH66_RS12460 Protein ID WP_002916312.1
Coordinates 2327969..2328235 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KLH66_RS12435 (2323119) 2323119..2324552 - 1434 WP_064158015.1 6-phospho-beta-glucosidase -
KLH66_RS12440 (2324671) 2324671..2325399 - 729 WP_032454033.1 MurR/RpiR family transcriptional regulator -
KLH66_RS12445 (2325450) 2325450..2325761 + 312 WP_064158016.1 N(4)-acetylcytidine aminohydrolase -
KLH66_RS12450 (2325925) 2325925..2326584 + 660 WP_008806429.1 hemolysin III family protein -
KLH66_RS12455 (2326740) 2326740..2327723 - 984 WP_064158017.1 tRNA-modifying protein YgfZ -
KLH66_RS12460 (2327969) 2327969..2328235 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KLH66_RS12465 (2328216) 2328216..2328626 + 411 WP_023290968.1 protein YgfX Toxin
KLH66_RS12470 (2328633) 2328633..2329154 - 522 WP_004205324.1 flavodoxin FldB -
KLH66_RS12475 (2329255) 2329255..2330151 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KLH66_RS12480 (2330174) 2330174..2330887 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KLH66_RS12485 (2330893) 2330893..2332626 + 1734 WP_032454029.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.89 Da        Isoelectric Point: 11.4778

>T204460 WP_023290968.1 NZ_CP075885:2328216-2328626 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T204460 NZ_CP100732:3637591-3637866 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT204460 WP_002916312.1 NZ_CP075885:2327969-2328235 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT204460 NZ_CP100732:c3637856-3637434 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N4VX63

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References