Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2366353..2367048 Replicon chromosome
Accession NC_002755
Organism Mycobacterium tuberculosis CDC1551

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag MT_RS11010 Protein ID WP_003410811.1
Coordinates 2366353..2366787 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag MT_RS11015 Protein ID WP_003410814.1
Coordinates 2366794..2367048 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT_RS11000 2362506..2365548 + 3043 Protein_2156 DEAD/DEAH box helicase -
MT_RS11005 2365541..2366374 + 834 WP_003899172.1 SWIM zinc finger family protein -
MT_RS11010 2366353..2366787 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
MT_RS11015 2366794..2367048 - 255 WP_003410814.1 antitoxin Antitoxin
MT_RS11020 2367064..2367321 - 258 WP_003410816.1 hypothetical protein -
MT_RS11025 2368268..2368564 + 297 WP_003410820.1 PE family protein -
MT_RS11030 2368620..2369351 + 732 WP_003900467.1 PPE family protein -
MT_RS11035 2369891..2370637 - 747 WP_003899174.1 proteasome subunit alpha -
MT_RS11040 2370634..2371509 - 876 WP_003411023.1 proteasome subunit beta -
MT_RS11045 2371506..2371700 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T20446 WP_003410811.1 NC_002755:c2366787-2366353 [Mycobacterium tuberculosis CDC1551]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T20446 NC_002755:c2366787-2366353 [Mycobacterium tuberculosis CDC1551]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT20446 WP_003410814.1 NC_002755:c2367048-2366794 [Mycobacterium tuberculosis CDC1551]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT20446 NC_002755:c2367048-2366794 [Mycobacterium tuberculosis CDC1551]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References