Detailed information of TA system TA204459

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1000376..1000847
• Replicon: chromosome
• Accession: NZ_CP075885
• Organism: Klebsiella quasipneumoniae strain JNQH473

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KLH66_RS06035
• Protein ID: WP_023291758.1
• Coordinates: 1000376..1000615 (-)
• Length: 80 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1C1EW86
• Locus tag: KLH66_RS06040
• Protein ID: WP_023291757.1
• Coordinates: 1000605..1000847 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KLH66_RS06025 (997329)	997329..999467	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
KLH66_RS06030 (999863)	999863..1000327	+	465	WP_012969085.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
KLH66_RS06035 (1000376)	1000376..1000615	-	240	WP_023291758.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KLH66_RS06040 (1000605)	1000605..1000847	-	243	WP_023291757.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KLH66_RS06045 (1000925)	1000925..1002835	-	1911	WP_044525201.1	PRD domain-containing protein	-
KLH66_RS06050 (1002858)	1002858..1004009	-	1152	WP_023291755.1	lactonase family protein	-
KLH66_RS06055 (1004076)	1004076..1004816	-	741	WP_017900574.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-79)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 80 a.a.
• Molecular weight: 9162.72 Da
• Isoelectric Point: 10.1315

>T204459 WP_023291758.1 NZ_CP075885:c1000615-1000376 [Klebsiella quasipneumoniae]
MTYELAFDPRAWREWQKLGETIKKQFKNKLQQVVQNPRIASASLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIG

Nucleotide

• Length: 240 bp

>T204459 NZ_CP100732:3406133-3406351 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9119.58 Da
• Isoelectric Point: 4.8146

>AT204459 WP_023291757.1 NZ_CP075885:c1000847-1000605 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDSEAALLRTVRERLENPQPEVKVSLDDL

Nucleotide

• Length: 243 bp

>AT204459 NZ_CP100732:3405731-3406105 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1C1EW86