Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 291454..292073 Replicon chromosome
Accession NZ_CP075885
Organism Klebsiella quasipneumoniae strain JNQH473

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KLH66_RS02680 Protein ID WP_002892050.1
Coordinates 291855..292073 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KLH66_RS02675 Protein ID WP_002892066.1
Coordinates 291454..291828 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KLH66_RS02665 (286608) 286608..287801 + 1194 WP_023288645.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KLH66_RS02670 (287824) 287824..290970 + 3147 WP_023288644.1 multidrug efflux RND transporter permease subunit AcrB -
KLH66_RS02675 (291454) 291454..291828 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KLH66_RS02680 (291855) 291855..292073 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KLH66_RS02685 (292232) 292232..292798 + 567 WP_023288643.1 maltose O-acetyltransferase -
KLH66_RS02690 (292770) 292770..292901 - 132 WP_032428629.1 hypothetical protein -
KLH66_RS02695 (292935) 292935..293405 + 471 WP_023288642.1 YlaC family protein -
KLH66_RS02700 (293374) 293374..294831 - 1458 WP_121936304.1 PLP-dependent aminotransferase family protein -
KLH66_RS02705 (294932) 294932..295630 + 699 WP_195806041.1 GNAT family protein -
KLH66_RS02710 (295627) 295627..295767 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KLH66_RS02715 (295767) 295767..296030 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T204458 WP_002892050.1 NZ_CP075885:291855-292073 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T204458 NZ_CP100732:2357176-2357460 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT204458 WP_002892066.1 NZ_CP075885:291454-291828 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT204458 NZ_CP100732:2356938-2357186 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References