Detailed information of TA system TA204453

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 5935361..5936180
• Replicon: chromosome
• Accession: NZ_CP075881
• Organism: Klebsiella michiganensis strain JNQH491

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: KLH67_RS28030
• Protein ID: WP_004110819.1
• Coordinates: 5935923..5936180 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: KLH67_RS28025
• Protein ID: WP_046877056.1
• Coordinates: 5935361..5935912 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KLH67_RS28010 (KLH67_28005)	5931585..5932493	-	909	WP_049104432.1	transcriptional regulator GcvA	-
KLH67_RS28015 (KLH67_28010)	5932613..5933500	+	888	WP_049084232.1	DMT family transporter	-
KLH67_RS31375	5933715..5934461	-	747	WP_223226754.1	class I SAM-dependent methyltransferase	-
KLH67_RS31380	5934888..5935247	-	360	Protein_5506	class I SAM-dependent methyltransferase	-
KLH67_RS28025 (KLH67_28020)	5935361..5935912	-	552	WP_046877056.1	N-acetyltransferase	Antitoxin
KLH67_RS28030 (KLH67_28025)	5935923..5936180	-	258	WP_004110819.1	YjhX family toxin	Toxin
KLH67_RS28035 (KLH67_28030)	5936856..5938040	+	1185	WP_014228054.1	mannonate dehydratase	-
KLH67_RS28040 (KLH67_28035)	5938114..5939589	+	1476	WP_014228053.1	fructuronate reductase	-
KLH67_RS28045 (KLH67_28040)	5939729..5940505	+	777	WP_004847986.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T204453 WP_004110819.1 NZ_CP075881:c5936180-5935923 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T204453 NZ_CP100732:365062-365337 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19998.88 Da
• Isoelectric Point: 6.3992

>AT204453 WP_046877056.1 NZ_CP075881:c5935912-5935361 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGGLIRHGIEQLKAMGSQMVFVLGHAAYYPRLGFEPCAGDKGYPAPYPIPEAHKACWMLQPLSS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT204453 NZ_CP100732:364799-365059 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2