204453

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 5935361..5936180 Replicon chromosome
Accession NZ_CP075881
Organism Klebsiella michiganensis strain JNQH491

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag KLH67_RS28030 Protein ID WP_004110819.1
Coordinates 5935923..5936180 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag KLH67_RS28025 Protein ID WP_046877056.1
Coordinates 5935361..5935912 (-) Length 184 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KLH67_RS28010 (KLH67_28005) 5931585..5932493 - 909 WP_049104432.1 transcriptional regulator GcvA -
KLH67_RS28015 (KLH67_28010) 5932613..5933500 + 888 WP_049084232.1 DMT family transporter -
KLH67_RS31375 5933715..5934461 - 747 WP_223226754.1 class I SAM-dependent methyltransferase -
KLH67_RS31380 5934888..5935247 - 360 Protein_5506 class I SAM-dependent methyltransferase -
KLH67_RS28025 (KLH67_28020) 5935361..5935912 - 552 WP_046877056.1 N-acetyltransferase Antitoxin
KLH67_RS28030 (KLH67_28025) 5935923..5936180 - 258 WP_004110819.1 YjhX family toxin Toxin
KLH67_RS28035 (KLH67_28030) 5936856..5938040 + 1185 WP_014228054.1 mannonate dehydratase -
KLH67_RS28040 (KLH67_28035) 5938114..5939589 + 1476 WP_014228053.1 fructuronate reductase -
KLH67_RS28045 (KLH67_28040) 5939729..5940505 + 777 WP_004847986.1 Uxu operon transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-85)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T204453 WP_004110819.1 NZ_CP075881:c5936180-5935923 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

>T204453 NZ_CP100732:365062-365337 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 19998.88 Da        Isoelectric Point: 6.3992

>AT204453 WP_046877056.1 NZ_CP075881:c5935912-5935361 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGGLIRHGIEQLKAMGSQMVFVLGHAAYYPRLGFEPCAGDKGYPAPYPIPEAHKACWMLQPLSS
QPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp

>AT204453 NZ_CP100732:364799-365059 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2


Antitoxin

Source ID Structure

References