204442

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1945122..1945779 Replicon chromosome
Accession NZ_CP075881
Organism Klebsiella michiganensis strain JNQH491

Toxin (Protein)


Gene name cptA Uniprot ID J5U333
Locus tag KLH67_RS09150 Protein ID WP_004854060.1
Coordinates 1945369..1945779 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag KLH67_RS09145 Protein ID WP_004124953.1
Coordinates 1945122..1945388 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KLH67_RS09130 (KLH67_09130) 1940356..1940781 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
KLH67_RS09135 (KLH67_09135) 1940902..1943700 - 2799 WP_214632560.1 transcriptional regulator DagR -
KLH67_RS09140 (KLH67_09140) 1943894..1944877 - 984 WP_014226793.1 tRNA-modifying protein YgfZ -
KLH67_RS09145 (KLH67_09145) 1945122..1945388 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
KLH67_RS09150 (KLH67_09150) 1945369..1945779 + 411 WP_004854060.1 protein YgfX Toxin
KLH67_RS09155 (KLH67_09155) 1945788..1946309 - 522 WP_014226792.1 flavodoxin FldB -
KLH67_RS09160 (KLH67_09160) 1946431..1947327 + 897 WP_046876662.1 site-specific tyrosine recombinase XerD -
KLH67_RS09165 (KLH67_09165) 1947350..1948063 + 714 WP_004854054.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KLH67_RS09170 (KLH67_09170) 1948069..1949802 + 1734 WP_014226791.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16106.97 Da        Isoelectric Point: 10.9455

>T204442 WP_004854060.1 NZ_CP075881:1945369-1945779 [Klebsiella michiganensis]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

>T204442 NZ_CP100728:2409725-2410009 [Salmonella enterica subsp. enterica serovar Blockley]
ATGACTTATAAGCTGGCATTTAACGAATCTGCACTAAAAGAGTGGAAAAAACTGGGTCATACTATACAGGAACAGTTTAA
AAAAAAGTTACGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT204442 WP_004124953.1 NZ_CP075881:1945122-1945388 [Klebsiella michiganensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT204442 NZ_CP100728:2409487-2409735 [Salmonella enterica subsp. enterica serovar Blockley]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References