Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 101445..101967 | Replicon | plasmid pS19_651-b |
| Accession | NZ_CP075854 | ||
| Organism | Escherichia coli strain S19-651 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1PVW2 |
| Locus tag | JFY28_RS26325 | Protein ID | WP_001681795.1 |
| Coordinates | 101686..101967 (+) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1Q9V6 |
| Locus tag | JFY28_RS26320 | Protein ID | WP_001681796.1 |
| Coordinates | 101445..101696 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JFY28_RS26295 (JFY28_026295) | 96861..97568 | - | 708 | WP_001114349.1 | A24 family peptidase | - |
| JFY28_RS26300 (JFY28_026300) | 97528..98010 | - | 483 | WP_021561187.1 | lytic transglycosylase domain-containing protein | - |
| JFY28_RS26305 (JFY28_026305) | 98058..98594 | - | 537 | WP_001011500.1 | type 4 pilus major pilin | - |
| JFY28_RS26310 (JFY28_026310) | 98644..99744 | - | 1101 | WP_135560891.1 | type II secretion system F family protein | - |
| JFY28_RS26315 (JFY28_026315) | 99746..101254 | - | 1509 | WP_012605185.1 | ATPase, T2SS/T4P/T4SS family | - |
| JFY28_RS26320 (JFY28_026320) | 101445..101696 | + | 252 | WP_001681796.1 | hypothetical protein | Antitoxin |
| JFY28_RS26325 (JFY28_026325) | 101686..101967 | + | 282 | WP_001681795.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JFY28_RS26330 (JFY28_026330) | 102006..102224 | - | 219 | WP_175125356.1 | hypothetical protein | - |
| JFY28_RS26335 (JFY28_026335) | 102277..102729 | - | 453 | WP_001681794.1 | type IV pilus biogenesis protein PilP | - |
| JFY28_RS26340 (JFY28_026340) | 102719..104014 | - | 1296 | WP_016238166.1 | type 4b pilus protein PilO2 | - |
| JFY28_RS26345 (JFY28_026345) | 104035..105654 | - | 1620 | WP_062859202.1 | PilN family type IVB pilus formation outer membrane protein | - |
| JFY28_RS26350 (JFY28_026350) | 105685..106122 | - | 438 | WP_001681791.1 | type IV pilus biogenesis protein PilM | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | hlyC / hlyA / hlyB / hlyD / espP | 1..114566 | 114566 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11122.01 Da Isoelectric Point: 10.6249
>T204435 WP_001681795.1 NZ_CP075854:101686-101967 [Escherichia coli]
MTYELEFERRALKEWHKLGHTVREQFKKKLSERLKNPRVPAARLHGHTDRYKIKLRASGYRLVYQVIDEKIVLLVIAVGK
RESSEVYQMADIR
MTYELEFERRALKEWHKLGHTVREQFKKKLSERLKNPRVPAARLHGHTDRYKIKLRASGYRLVYQVIDEKIVLLVIAVGK
RESSEVYQMADIR
Download Length: 282 bp
>T204435 NZ_CP100728:218101-218586 [Salmonella enterica subsp. enterica serovar Blockley]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTCGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTACAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCAATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTCGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTACAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCAATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9124.33 Da Isoelectric Point: 4.0610
>AT204435 WP_001681796.1 NZ_CP075854:101445-101696 [Escherichia coli]
MSYQILTTTAASITELKKNPMGTVAEGEGGAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVKVSL
DDL
MSYQILTTTAASITELKKNPMGTVAEGEGGAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVKVSL
DDL
Download Length: 252 bp
>AT204435 NZ_CP100728:217826-218113 [Salmonella enterica subsp. enterica serovar Blockley]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCAGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCAGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|