Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1779..2326 Replicon plasmid pS19_651-b
Accession NZ_CP075854
Organism Escherichia coli strain S19-651

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag JFY28_RS25850 Protein ID WP_001384452.1
Coordinates 2048..2326 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID W0FTF6
Locus tag JFY28_RS25845 Protein ID WP_000079942.1
Coordinates 1779..2048 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFY28_RS25840 (JFY28_025840) 1..873 + 873 WP_021553143.1 incFII family plasmid replication initiator RepA -
JFY28_RS25845 (JFY28_025845) 1779..2048 + 270 WP_000079942.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
JFY28_RS25850 (JFY28_025850) 2048..2326 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
JFY28_RS25855 (JFY28_025855) 2582..3767 - 1186 Protein_3 IS91 family transposase -
JFY28_RS25860 (JFY28_025860) 3767..4132 - 366 WP_033804494.1 hypothetical protein -
JFY28_RS25865 (JFY28_025865) 4468..5076 - 609 WP_198798515.1 ProQ/FINO family protein -
JFY28_RS25870 (JFY28_025870) 5630..6097 + 468 Protein_6 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - hlyC / hlyA / hlyB / hlyD / espP 1..114566 114566


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T204434 WP_001384452.1 NZ_CP075854:2048-2326 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T204434 NZ_CP100727:3679-4194 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAATTTTACACAATATCAAGCAGTTACATAAAATACCTGAAGGACTTTGATGACAAAGTTCCCAATAGCGAAGATCC
TACATACAACAATCCTAAGGCTTTCATTGGCATAGTACTAGAGATTGAAGGACATAAATATTTAGCACCTTTAACATCGC
CAAAAGCATGGCATGCTAATGTAAAAGAGTCATCACCCGCCTTCTTCAAACTTCATGAAAACGGTGTCCCTGATAATCAG
CTTGGATTGATTAATCTGAAATTTATGATTCCAATAATCGAAGCTGAAGTGTCTTTACTTGATCTGGATAGCATGCCTGA
TACGCCTTACAAAAGAATGCTATATAAACAGTTACAATTTATTCGTGTAAATGAAGATAAAATATCTGAAAAATCAAAAC
TATTAAGAAACCTTGCCTTGCAAGGCAGAATGCAAAGAACATGCGACTTTGCCGTGTTAGAAGAAAAATATCAACATTTC
GGTAAAAAACCTGAAGACATGGAAATAGACGATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10282.61 Da        Isoelectric Point: 7.2057

>AT204434 WP_000079942.1 NZ_CP075854:1779-2048 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSATAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT204434 NZ_CP100727:3570-3627 [Salmonella enterica subsp. enterica serovar Enteritidis]
AGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTTAGGTCATTTACTACCTTAAAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A140JYS5

References