Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4206573..4207198 Replicon chromosome
Accession NZ_CP075852
Organism Escherichia coli strain S19-651

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JFY28_RS20535 Protein ID WP_000911330.1
Coordinates 4206800..4207198 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag JFY28_RS20530 Protein ID WP_000450524.1
Coordinates 4206573..4206800 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFY28_RS20505 (4202376) 4202376..4202846 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
JFY28_RS20510 (4202846) 4202846..4203418 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
JFY28_RS20515 (4203564) 4203564..4204442 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
JFY28_RS20520 (4204459) 4204459..4205493 + 1035 WP_001330579.1 outer membrane protein assembly factor BamC -
JFY28_RS20525 (4205706) 4205706..4206419 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
JFY28_RS20530 (4206573) 4206573..4206800 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
JFY28_RS20535 (4206800) 4206800..4207198 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
JFY28_RS20540 (4207345) 4207345..4208208 + 864 WP_001267498.1 neutral zinc metallopeptidase -
JFY28_RS20545 (4208223) 4208223..4210238 + 2016 WP_032330806.1 tRNA cytosine(34) acetyltransferase TmcA -
JFY28_RS20550 (4210312) 4210312..4211010 + 699 WP_000679812.1 esterase -
JFY28_RS20555 (4211120) 4211120..4211320 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T204418 WP_000911330.1 NZ_CP075852:4206800-4207198 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T204418 NZ_CP100724:c904581-904183 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT204418 WP_000450524.1 NZ_CP075852:4206573-4206800 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT204418 NZ_CP100724:c904808-904581 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References