Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3036743..3037329 Replicon chromosome
Accession NZ_CP075852
Organism Escherichia coli strain S19-651

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag JFY28_RS14695 Protein ID WP_042014162.1
Coordinates 3036743..3036973 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag JFY28_RS14700 Protein ID WP_000593555.1
Coordinates 3036970..3037329 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFY28_RS14685 (3032780) 3032780..3035515 + 2736 WP_032331058.1 ribosome-associated ATPase/putative transporter RbbA -
JFY28_RS14690 (3035515) 3035515..3036639 + 1125 WP_001216257.1 ABC transporter permease -
JFY28_RS14695 (3036743) 3036743..3036973 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
JFY28_RS14700 (3036970) 3036970..3037329 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JFY28_RS14705 (3037449) 3037449..3037850 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
JFY28_RS14710 (3037856) 3037856..3038662 - 807 WP_032331057.1 nickel import ATP-binding protein NikE -
JFY28_RS14715 (3038659) 3038659..3039423 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
JFY28_RS14720 (3039423) 3039423..3040256 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
JFY28_RS14725 (3040253) 3040253..3041197 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T204413 WP_042014162.1 NZ_CP075852:3036743-3036973 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T204413 NZ_CP100719:45736-46041 [Salmonella enterica subsp. enterica serovar Weltevreden]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGACAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGTCTTACCGCCTGCTGACCACGGATATGGCCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTGCAGGAGAATGACATCAGAAATGCCATTAACCTGATGTTCCGGGGGGTCTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT204413 WP_000593555.1 NZ_CP075852:3036970-3037329 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT204413 NZ_CP100719:45516-45734 [Salmonella enterica subsp. enterica serovar Weltevreden]
ATGAAGCAGCGCATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAGGGAATACGACGTGAATATCTCCGGCCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGCGCCGGACGCTGGCAGGAAGAAAACCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTGACGGATCGTTTGCTGACGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References