Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2230072..2230970 Replicon chromosome
Accession NC_002755
Organism Mycobacterium tuberculosis CDC1551

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag MT_RS10390 Protein ID WP_003410001.1
Coordinates 2230072..2230632 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag MT_RS10395 Protein ID WP_003410003.1
Coordinates 2230629..2230970 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT_RS10360 2225241..2225894 - 654 WP_003409976.1 cutinase Cfp21 -
MT_RS10365 2226009..2226239 + 231 WP_003409980.1 DUF167 domain-containing protein -
MT_RS10370 2226324..2227235 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
MT_RS10375 2227344..2227943 + 600 WP_003409989.1 L-lysine exporter -
MT_RS10380 2228359..2228787 + 429 WP_003409992.1 cellulose-binding protein -
MT_RS10385 2229013..2229552 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
MT_RS10390 2230072..2230632 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
MT_RS10395 2230629..2230970 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
MT_RS10400 2231056..2231313 + 258 WP_003917558.1 hypothetical protein -
MT_RS10405 2231214..2231549 - 336 WP_003410009.1 dehydrogenase -
MT_RS10410 2231638..2231982 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
MT_RS10415 2231976..2232224 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
MT_RS10420 2232324..2234639 - 2316 WP_003899120.1 cation transporter ATPase CptG -
MT_RS10425 2234636..2234908 - 273 WP_003410017.1 DUF1490 family protein -
MT_RS10430 2234961..2235317 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T20441 WP_003410001.1 NC_002755:c2230632-2230072 [Mycobacterium tuberculosis CDC1551]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T20441 NC_002755:c2230632-2230072 [Mycobacterium tuberculosis CDC1551]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT20441 WP_003410003.1 NC_002755:c2230970-2230629 [Mycobacterium tuberculosis CDC1551]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT20441 NC_002755:c2230970-2230629 [Mycobacterium tuberculosis CDC1551]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References