Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 650386..650864 Replicon chromosome
Accession NZ_CP075852
Organism Escherichia coli strain S19-651

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A7D8WGY6
Locus tag JFY28_RS03460 Protein ID WP_000936798.1
Coordinates 650577..650864 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID D8A5B4
Locus tag JFY28_RS03455 Protein ID WP_000100899.1
Coordinates 650386..650577 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFY28_RS03405 (645865) 645865..646089 - 225 WP_021577603.1 hypothetical protein -
JFY28_RS03410 (646086) 646086..646436 - 351 WP_254210624.1 DUF4406 domain-containing protein -
JFY28_RS03420 (646433) 646433..646825 - 393 WP_198798412.1 DUF977 family protein -
JFY28_RS03425 (646841) 646841..647566 - 726 WP_198798411.1 DUF1627 domain-containing protein -
JFY28_RS03430 (647600) 647600..648061 - 462 WP_000139447.1 replication protein P -
JFY28_RS03435 (648054) 648054..649067 - 1014 WP_198798410.1 DUF1376 domain-containing protein -
JFY28_RS03440 (649154) 649154..649591 - 438 WP_000693932.1 toxin YdaT family protein -
JFY28_RS03445 (649575) 649575..649847 - 273 WP_000887447.1 YdaS family helix-turn-helix protein -
JFY28_RS03450 (649957) 649957..650358 + 402 WP_001329851.1 helix-turn-helix domain-containing protein -
JFY28_RS03455 (650386) 650386..650577 + 192 WP_000100899.1 hypothetical protein Antitoxin
JFY28_RS03460 (650577) 650577..650864 + 288 WP_000936798.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JFY28_RS03465 (651137) 651137..651292 + 156 WP_000379557.1 DUF1391 family protein -
JFY28_RS03470 (651452) 651452..651670 + 219 WP_001171946.1 protein YdfC -
JFY28_RS03475 (652252) 652252..652440 + 189 WP_000449172.1 cell division inhibition protein DicB -
JFY28_RS03480 (652437) 652437..652625 + 189 WP_071995903.1 DUF1482 family protein -
JFY28_RS03485 (652718) 652718..655162 + 2445 WP_062861044.1 exonuclease -
JFY28_RS03490 (655224) 655224..655493 + 270 WP_000003742.1 excisionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 547158..663749 116591


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10899.83 Da        Isoelectric Point: 10.1360

>T204403 WP_000936798.1 NZ_CP075852:650577-650864 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENIPAARRLKIRIETSVLALSEHPYLYPPSDRVSGLREIVVHPNYIVLYRVAASSIE
IANIVHARRQFPFPI

Download         Length: 288 bp

>T204403 NZ_CP100718:3624202-3624420 [Salmonella enterica subsp. enterica serovar Weltevreden]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7035.80 Da        Isoelectric Point: 4.0270

>AT204403 WP_000100899.1 NZ_CP075852:650386-650577 [Escherichia coli]
MSTALSPIVSEFETTEQENSYNEWLRAKVASSLADPRPSIPHDEVMAEMENLIAQIAVTNRSE

Download         Length: 192 bp

>AT204403 NZ_CP100718:3623800-3624174 [Salmonella enterica subsp. enterica serovar Weltevreden]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTATAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D8WGY6

Antitoxin

Source ID Structure
AlphaFold DB A0A161RC07

References