Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 224741..225379 Replicon chromosome
Accession NZ_CP075852
Organism Escherichia coli strain S19-651

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag JFY28_RS01110 Protein ID WP_000813794.1
Coordinates 225203..225379 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JFY28_RS01105 Protein ID WP_001270286.1
Coordinates 224741..225157 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFY28_RS01085 (219893) 219893..220834 - 942 WP_032331454.1 ABC transporter permease -
JFY28_RS01090 (220835) 220835..221848 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
JFY28_RS01095 (221866) 221866..223011 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
JFY28_RS01100 (223256) 223256..224662 - 1407 WP_032331455.1 PLP-dependent aminotransferase family protein -
JFY28_RS01105 (224741) 224741..225157 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JFY28_RS01110 (225203) 225203..225379 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JFY28_RS01115 (225601) 225601..225831 + 231 WP_000494244.1 YncJ family protein -
JFY28_RS01120 (225923) 225923..227884 - 1962 WP_024178299.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JFY28_RS01125 (227957) 227957..228493 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
JFY28_RS01130 (228585) 228585..229760 + 1176 WP_001236258.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 229800..231065 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T204402 WP_000813794.1 NZ_CP075852:c225379-225203 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T204402 NZ_CP100718:c2749501-2749398 [Salmonella enterica subsp. enterica serovar Weltevreden]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT204402 WP_001270286.1 NZ_CP075852:c225157-224741 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT204402 NZ_CP100718:2749396-2749539 [Salmonella enterica subsp. enterica serovar Weltevreden]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References