Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2222746..2223434 Replicon chromosome
Accession NC_002755
Organism Mycobacterium tuberculosis CDC1551

Toxin (Protein)


Gene name vapC Uniprot ID P9WF64
Locus tag MT_RS10345 Protein ID WP_003899117.1
Coordinates 2222746..2223165 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag MT_RS10350 Protein ID WP_003409968.1
Coordinates 2223174..2223434 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT_RS10325 2218241..2219089 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
MT_RS10330 2219052..2220497 - 1446 WP_003899115.1 APC family permease -
MT_RS10335 2220676..2221362 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
MT_RS10340 2221553..2222521 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
MT_RS10345 2222746..2223165 - 420 WP_003899117.1 type II toxin-antitoxin system VapC family toxin Toxin
MT_RS10350 2223174..2223434 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MT_RS10355 2223577..2225253 + 1677 WP_010924471.1 PecA family PE domain-processing aspartic protease -
MT_RS10360 2225241..2225894 - 654 WP_003409976.1 cutinase Cfp21 -
MT_RS10365 2226009..2226239 + 231 WP_003409980.1 DUF167 domain-containing protein -
MT_RS10370 2226324..2227235 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
MT_RS10375 2227344..2227943 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14748.87 Da        Isoelectric Point: 7.9722

>T20440 WP_003899117.1 NC_002755:c2223165-2222746 [Mycobacterium tuberculosis CDC1551]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDHEFRGVVGYWPGVA

Download         Length: 420 bp

>T20440 NC_002755:c2223165-2222746 [Mycobacterium tuberculosis CDC1551]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCATGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT20440 WP_003409968.1 NC_002755:c2223434-2223174 [Mycobacterium tuberculosis CDC1551]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT20440 NC_002755:c2223434-2223174 [Mycobacterium tuberculosis CDC1551]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7TLI0

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References