Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2201013..2201557 Replicon chromosome
Accession NC_002755
Organism Mycobacterium tuberculosis CDC1551

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag MT_RS10220 Protein ID WP_003409896.1
Coordinates 2201013..2201309 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag MT_RS10225 Protein ID WP_003409899.1
Coordinates 2201306..2201557 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT_RS10165 2196046..2196396 - 351 WP_003899096.1 hypothetical protein -
MT_RS10170 2196407..2197309 - 903 WP_003899097.1 hypothetical protein -
MT_RS10175 2197330..2197521 - 192 WP_003409876.1 hypothetical protein -
MT_RS10180 2197522..2197818 - 297 WP_003409877.1 hypothetical protein -
MT_RS10185 2198058..2198273 + 216 WP_003409878.1 antitoxin -
MT_RS10190 2198270..2198581 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
MT_RS22375 2198555..2199076 - 522 WP_003904745.1 hypothetical protein -
MT_RS10200 2199051..2199428 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
MT_RS10205 2199470..2199919 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
MT_RS10210 2199916..2200461 + 546 WP_003899098.1 SecB-like chaperone -
MT_RS10215 2200350..2200964 - 615 WP_003901296.1 hypothetical protein -
MT_RS10220 2201013..2201309 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MT_RS10225 2201306..2201557 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
MT_RS10230 2201544..2202038 + 495 WP_003917554.1 hypothetical protein -
MT_RS10235 2202198..2202605 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
MT_RS10240 2202609..2202881 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MT_RS10245 2202914..2204134 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
MT_RS10255 2205033..2205830 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T20439 WP_003409896.1 NC_002755:c2201309-2201013 [Mycobacterium tuberculosis CDC1551]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T20439 NC_002755:c2201309-2201013 [Mycobacterium tuberculosis CDC1551]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT20439 WP_003409899.1 NC_002755:c2201557-2201306 [Mycobacterium tuberculosis CDC1551]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT20439 NC_002755:c2201557-2201306 [Mycobacterium tuberculosis CDC1551]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References