Detailed information of TA system TA020437

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2191976..2192679
• Replicon: chromosome
• Accession: NC_002755
• Organism: Mycobacterium tuberculosis CDC1551

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: G0TLK7
• Locus tag: MT_RS10130
• Protein ID: WP_003409778.1
• Coordinates: 2191976..2192305 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: G0TLK8
• Locus tag: MT_RS21220
• Protein ID: WP_003409780.1
• Coordinates: 2192302..2192679 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MT_RS10110	2188359..2189429	+	1071	WP_003899091.1	epoxide hydrolase EphB	-
MT_RS10115	2189426..2189941	+	516	WP_003409718.1	flavin reductase family protein	-
MT_RS10120	2189938..2190999	+	1062	WP_003899092.1	3,4-dihydroxy-2-butanone-4-phosphate synthase	-
MT_RS10125	2190996..2191766	+	771	WP_003409775.1	SDR family oxidoreductase	-
MT_RS10130	2191976..2192305	-	330	WP_003409778.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MT_RS21220	2192302..2192679	-	378	WP_003409780.1	type II toxin-antitoxin system antitoxin MazE5	Antitoxin
MT_RS10140	2192676..2193266	-	591	WP_003409784.1	SEC-C domain-containing protein	-
MT_RS10145	2193321..2194685	+	1365	WP_003903691.1	HNH endonuclease	-
MT_RS10150	2194840..2195292	-	453	WP_003899095.1	lipoprotein	-
MT_RS10155	2195356..2195757	+	402	WP_003409869.1	hypothetical protein	-
MT_RS10160	2195750..2195932	-	183	WP_003409870.1	hypothetical protein	-
MT_RS10165	2196046..2196396	-	351	WP_003899096.1	hypothetical protein	-
MT_RS10170	2196407..2197309	-	903	WP_003899097.1	hypothetical protein	-
MT_RS10175	2197330..2197521	-	192	WP_003409876.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-103)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 11787.82 Da
• Isoelectric Point: 8.5361

>T20437 WP_003409778.1 NC_002755:c2192305-2191976 [Mycobacterium tuberculosis CDC1551]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Nucleotide

• Length: 330 bp

>T20437 NC_002755:c2192305-2191976 [Mycobacterium tuberculosis CDC1551]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13560.07 Da
• Isoelectric Point: 5.1519

>AT20437 WP_003409780.1 NC_002755:c2192679-2192302 [Mycobacterium tuberculosis CDC1551]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Nucleotide

• Length: 378 bp

>AT20437 NC_002755:c2192679-2192302 [Mycobacterium tuberculosis CDC1551]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Structures

Toxin

• AlphaFold DB: G0TLK7

Antitoxin

• AlphaFold DB: G0TLK8