Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4223291..4223886 Replicon chromosome
Accession NZ_CP075731
Organism Escherichia coli strain CP52E

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag KKZ11_RS20465 Protein ID WP_089601988.1
Coordinates 4223291..4223641 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID -
Locus tag KKZ11_RS20470 Protein ID WP_136698564.1
Coordinates 4223635..4223886 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKZ11_RS20445 (4218740) 4218740..4219762 - 1023 WP_122992735.1 ABC transporter permease -
KKZ11_RS20450 (4219776) 4219776..4221278 - 1503 WP_136698562.1 sugar ABC transporter ATP-binding protein -
KKZ11_RS20455 (4221418) 4221418..4222374 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
KKZ11_RS20460 (4222684) 4222684..4223214 + 531 WP_000055072.1 inorganic diphosphatase -
KKZ11_RS20465 (4223291) 4223291..4223641 - 351 WP_089601988.1 endoribonuclease toxin ChpB Toxin
KKZ11_RS20470 (4223635) 4223635..4223886 - 252 WP_136698564.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
KKZ11_RS20475 (4224098) 4224098..4224439 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
KKZ11_RS20480 (4224442) 4224442..4228221 - 3780 WP_136698565.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12493.41 Da        Isoelectric Point: 5.6219

>T204356 WP_089601988.1 NZ_CP075731:c4223641-4223291 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGITLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T204356 NZ_CP100707:3689743-3690018 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9327.69 Da        Isoelectric Point: 4.4201

>AT204356 WP_136698564.1 NZ_CP075731:c4223886-4223635 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPVGD
EIW

Download         Length: 252 bp

>AT204356 NZ_CP100707:c3690008-3689586 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References