Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3719987..3720821 Replicon chromosome
Accession NZ_CP075731
Organism Escherichia coli strain CP52E

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2X7CAN1
Locus tag KKZ11_RS17950 Protein ID WP_039025883.1
Coordinates 3719987..3720364 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2X5LBZ2
Locus tag KKZ11_RS17955 Protein ID WP_039025882.1
Coordinates 3720453..3720821 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKZ11_RS17915 (3715416) 3715416..3715637 + 222 WP_000691994.1 DUF987 domain-containing protein -
KKZ11_RS17920 (3715656) 3715656..3715973 + 318 WP_000070396.1 type IV toxin-antitoxin system antitoxin YafW -
KKZ11_RS17925 (3715994) 3715994..3716335 + 342 WP_000854680.1 type IV toxin-antitoxin system toxin YkfI -
KKZ11_RS17930 (3716928) 3716928..3718247 + 1320 WP_105284452.1 site-specific integrase -
KKZ11_RS17935 (3718340) 3718340..3719188 - 849 WP_039025884.1 DUF4942 domain-containing protein -
KKZ11_RS17940 (3719285) 3719285..3719482 - 198 WP_000772024.1 DUF957 domain-containing protein -
KKZ11_RS17945 (3719502) 3719502..3719990 - 489 Protein_3516 DUF5983 family protein -
KKZ11_RS17950 (3719987) 3719987..3720364 - 378 WP_039025883.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
KKZ11_RS17955 (3720453) 3720453..3720821 - 369 WP_039025882.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KKZ11_RS17960 (3720871) 3720871..3721515 - 645 WP_136698443.1 antitoxin of toxin-antitoxin stability system -
KKZ11_RS17965 (3721530) 3721530..3721751 - 222 WP_000692312.1 DUF987 domain-containing protein -
KKZ11_RS17970 (3721820) 3721820..3722296 - 477 WP_001186745.1 RadC family protein -
KKZ11_RS17975 (3722311) 3722311..3722796 - 486 WP_000214316.1 antirestriction protein -
KKZ11_RS17980 (3722887) 3722887..3723705 - 819 WP_001234702.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14176.22 Da        Isoelectric Point: 7.8523

>T204353 WP_039025883.1 NZ_CP075731:c3720364-3719987 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQLEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Download         Length: 378 bp

>T204353 NZ_CP100707:2092318-2092421 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13792.52 Da        Isoelectric Point: 5.9582

>AT204353 WP_039025882.1 NZ_CP075731:c3720821-3720453 [Escherichia coli]
VSDTFHETNYPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT204353 NZ_CP100707:c2092423-2092278 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X7CAN1

Antitoxin

Source ID Structure
AlphaFold DB A0A2X5LBZ2

References