Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yafW-ykfI/CbtA-CbeA |
| Location | 3715656..3716335 | Replicon | chromosome |
| Accession | NZ_CP075731 | ||
| Organism | Escherichia coli strain CP52E | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | S1FHS4 |
| Locus tag | KKZ11_RS17925 | Protein ID | WP_000854680.1 |
| Coordinates | 3715994..3716335 (+) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yafW | Uniprot ID | S1EWR7 |
| Locus tag | KKZ11_RS17920 | Protein ID | WP_000070396.1 |
| Coordinates | 3715656..3715973 (+) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KKZ11_RS17875 (3711093) | 3711093..3711914 | + | 822 | WP_136698440.1 | DUF932 domain-containing protein | - |
| KKZ11_RS17880 (3712131) | 3712131..3712832 | + | 702 | WP_136698441.1 | WYL domain-containing protein | - |
| KKZ11_RS17885 (3712873) | 3712873..3713109 | + | 237 | WP_001144031.1 | protein YpjK | - |
| KKZ11_RS17890 (3713109) | 3713109..3713552 | + | 444 | WP_029039038.1 | hypothetical protein | - |
| KKZ11_RS17895 (3713576) | 3713576..3714043 | + | 468 | WP_136698442.1 | protein YkfB | - |
| KKZ11_RS17900 (3714120) | 3714120..3714359 | + | 240 | WP_000194654.1 | DUF905 family protein | - |
| KKZ11_RS17905 (3714457) | 3714457..3714915 | + | 459 | WP_000211838.1 | antirestriction protein | - |
| KKZ11_RS17910 (3714931) | 3714931..3715407 | + | 477 | WP_000811693.1 | RadC family protein | - |
| KKZ11_RS17915 (3715416) | 3715416..3715637 | + | 222 | WP_000691994.1 | DUF987 domain-containing protein | - |
| KKZ11_RS17920 (3715656) | 3715656..3715973 | + | 318 | WP_000070396.1 | type IV toxin-antitoxin system antitoxin YafW | Antitoxin |
| KKZ11_RS17925 (3715994) | 3715994..3716335 | + | 342 | WP_000854680.1 | type IV toxin-antitoxin system toxin YkfI | Toxin |
| KKZ11_RS17930 (3716928) | 3716928..3718247 | + | 1320 | WP_105284452.1 | site-specific integrase | - |
| KKZ11_RS17935 (3718340) | 3718340..3719188 | - | 849 | WP_039025884.1 | DUF4942 domain-containing protein | - |
| KKZ11_RS17940 (3719285) | 3719285..3719482 | - | 198 | WP_000772024.1 | DUF957 domain-containing protein | - |
| KKZ11_RS17945 (3719502) | 3719502..3719990 | - | 489 | Protein_3516 | DUF5983 family protein | - |
| KKZ11_RS17950 (3719987) | 3719987..3720364 | - | 378 | WP_039025883.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | - |
| KKZ11_RS17955 (3720453) | 3720453..3720821 | - | 369 | WP_039025882.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12892.95 Da Isoelectric Point: 9.6543
>T204352 WP_000854680.1 NZ_CP075731:3715994-3716335 [Escherichia coli]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
Download Length: 342 bp
>T204352 NZ_CP100707:c1028595-1028068 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11982.62 Da Isoelectric Point: 7.0270
>AT204352 WP_000070396.1 NZ_CP075731:3715656-3715973 [Escherichia coli]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
Download Length: 318 bp
>AT204352 NZ_CP100707:c1028882-1028592 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|