Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3500109..3500727 Replicon chromosome
Accession NZ_CP075731
Organism Escherichia coli strain CP52E

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KKZ11_RS16885 Protein ID WP_001291435.1
Coordinates 3500509..3500727 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag KKZ11_RS16880 Protein ID WP_089601776.1
Coordinates 3500109..3500483 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKZ11_RS16870 (3495637) 3495637..3498786 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
KKZ11_RS16880 (3500109) 3500109..3500483 + 375 WP_089601776.1 Hha toxicity modulator TomB Antitoxin
KKZ11_RS16885 (3500509) 3500509..3500727 + 219 WP_001291435.1 HHA domain-containing protein Toxin
KKZ11_RS16890 (3500899) 3500899..3501450 + 552 WP_000102564.1 maltose O-acetyltransferase -
KKZ11_RS16895 (3501566) 3501566..3502036 + 471 WP_000136192.1 YlaC family protein -
KKZ11_RS16900 (3502200) 3502200..3503750 + 1551 WP_001469946.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KKZ11_RS16905 (3503792) 3503792..3504145 - 354 Protein_3309 DUF1428 family protein -
KKZ11_RS16915 (3504524) 3504524..3504835 + 312 WP_000409911.1 MGMT family protein -
KKZ11_RS16920 (3504866) 3504866..3505438 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T204350 WP_001291435.1 NZ_CP075731:3500509-3500727 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T204350 NZ_CP100707:870592-871005 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14587.42 Da        Isoelectric Point: 4.7395

>AT204350 WP_089601776.1 NZ_CP075731:3500109-3500483 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSSNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT204350 NZ_CP100707:870345-870611 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References