204337

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 871122..871776 Replicon chromosome
Accession NZ_CP075731
Organism Escherichia coli strain CP52E

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag KKZ11_RS04280 Protein ID WP_097346894.1
Coordinates 871369..871776 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag KKZ11_RS04275 Protein ID WP_000354046.1
Coordinates 871122..871388 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKZ11_RS04250 (866291) 866291..867034 + 744 WP_000951948.1 SDR family oxidoreductase -
KKZ11_RS04255 (867091) 867091..868524 - 1434 WP_040062540.1 6-phospho-beta-glucosidase BglA -
KKZ11_RS04260 (868569) 868569..868880 + 312 WP_001182947.1 N(4)-acetylcytidine aminohydrolase -
KKZ11_RS04265 (869044) 869044..869703 + 660 WP_000250274.1 hemolysin III family protein -
KKZ11_RS04270 (869899) 869899..870879 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
KKZ11_RS04275 (871122) 871122..871388 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
KKZ11_RS04280 (871369) 871369..871776 + 408 WP_097346894.1 protein YgfX Toxin
KKZ11_RS04285 (871816) 871816..872337 - 522 WP_001055874.1 flavodoxin FldB -
KKZ11_RS04290 (872449) 872449..873345 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
KKZ11_RS04295 (873370) 873370..874080 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KKZ11_RS04300 (874086) 874086..875819 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16005.88 Da        Isoelectric Point: 11.5202

>T204337 WP_097346894.1 NZ_CP075731:871369-871776 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLSMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T204337 NZ_CP100702:1978799-1978902 [Salmonella enterica subsp. enterica serovar Thompson]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT204337 WP_000354046.1 NZ_CP075731:871122-871388 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT204337 NZ_CP100702:c1978904-1978759 [Salmonella enterica subsp. enterica serovar Thompson]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References