Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 35989..36536 Replicon plasmid unnamed.1
Accession NZ_CP075724
Organism Escherichia coli strain CPE35

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag KKZ10_RS23180 Protein ID WP_001384452.1
Coordinates 36258..36536 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1M1SX19
Locus tag KKZ10_RS23175 Protein ID WP_021546940.1
Coordinates 35989..36258 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKZ10_RS23150 (KKZ10_23040) 31483..31734 + 252 WP_023281067.1 hypothetical protein -
KKZ10_RS23155 (KKZ10_23045) 31768..32465 + 698 WP_103215986.1 IS1-like element IS1A family transposase -
KKZ10_RS23160 (KKZ10_23050) 32806..33795 + 990 WP_001515196.1 tyrosine-type recombinase/integrase -
KKZ10_RS23165 (KKZ10_23055) 33843..34181 - 339 WP_063116667.1 hypothetical protein -
KKZ10_RS23175 (KKZ10_23065) 35989..36258 + 270 WP_021546940.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
KKZ10_RS23180 (KKZ10_23070) 36258..36536 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
KKZ10_RS23185 (KKZ10_23075) 36582..36794 + 213 Protein_43 3'-5' exonuclease -
KKZ10_RS23190 (KKZ10_23080) 36889..37125 + 237 WP_223417154.1 transposase -
KKZ10_RS23195 (KKZ10_23085) 37378..39195 - 1818 Protein_45 Tn3-like element TnAs1 family transposase -
KKZ10_RS23200 (KKZ10_23090) 39261..39965 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
KKZ10_RS23205 (KKZ10_23095) 39971..40111 + 141 WP_001044210.1 hypothetical protein -
KKZ10_RS23210 (KKZ10_23100) 40597..41334 + 738 WP_001446887.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid ant(3'')-Ia / blaTEM-1B / tet(M) / aph(3')-Ia / sul3 / cmlA1 / aadA2 / dfrA12 / aph(3'')-Ib / aph(6)-Id - 1..91697 91697
- inside IScluster/Tn ant(3'')-Ia / blaTEM-1B / tet(M) / aph(3')-Ia / sul3 / cmlA1 / aadA2 / dfrA12 / aph(3'')-Ib / aph(6)-Id - 31768..90786 59018


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T204332 WP_001384452.1 NZ_CP075724:36258-36536 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T204332 NZ_CP100702:205201-205686 [Salmonella enterica subsp. enterica serovar Thompson]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10321.69 Da        Isoelectric Point: 8.8725

>AT204332 WP_021546940.1 NZ_CP075724:35989-36258 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMRRKVADK

Download         Length: 270 bp

>AT204332 NZ_CP100702:204926-205213 [Salmonella enterica subsp. enterica serovar Thompson]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1SX19

References