Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1686427..1687043 Replicon chromosome
Accession NC_002755
Organism Mycobacterium tuberculosis CDC1551

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag MT_RS07915 Protein ID WP_003407593.1
Coordinates 1686726..1687043 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ90
Locus tag MT_RS07910 Protein ID WP_003917487.1
Coordinates 1686427..1686729 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT_RS07900 1682313..1684160 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
MT_RS07905 1684161..1686413 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
MT_RS07910 1686427..1686729 + 303 WP_003917487.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
MT_RS07915 1686726..1687043 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
MT_RS07920 1687040..1688044 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
MT_RS07925 1688097..1689386 + 1290 WP_003407599.1 serine hydrolase -
MT_RS07930 1689459..1690232 - 774 WP_102770481.1 class I SAM-dependent methyltransferase -
MT_RS07935 1690290..1690502 - 213 WP_003898900.1 dodecin family protein -
MT_RS22365 1690512..1690736 - 225 WP_160522526.1 NUDIX domain-containing protein -
MT_RS07945 1691006..1692034 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T20433 WP_003407593.1 NC_002755:1686726-1687043 [Mycobacterium tuberculosis CDC1551]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T20433 NC_002755:1686726-1687043 [Mycobacterium tuberculosis CDC1551]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11154.38 Da        Isoelectric Point: 8.5413

>AT20433 WP_003917487.1 NC_002755:1686427-1686729 [Mycobacterium tuberculosis CDC1551]
VPFLVALSGIISGVHDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT20433 NC_002755:1686427-1686729 [Mycobacterium tuberculosis CDC1551]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCATGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
AlphaFold DB P9WJ90

References