Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 54386..54908 | Replicon | plasmid pCPWW7-IncI2 |
| Accession | NZ_CP075719 | ||
| Organism | Escherichia coli strain CPww7 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | U9YLU1 |
| Locus tag | KKZ15_RS25420 | Protein ID | WP_000638823.1 |
| Coordinates | 54386..54667 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U9Y7J1 |
| Locus tag | KKZ15_RS25425 | Protein ID | WP_000121741.1 |
| Coordinates | 54657..54908 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KKZ15_RS25385 (KKZ15_25270) | 50535..50855 | - | 321 | WP_000362080.1 | VirB3 family type IV secretion system protein | - |
| KKZ15_RS25390 | 50926..51216 | - | 291 | WP_000865479.1 | conjugal transfer protein | - |
| KKZ15_RS25395 (KKZ15_25280) | 51216..51800 | - | 585 | WP_001177113.1 | lytic transglycosylase domain-containing protein | - |
| KKZ15_RS25400 (KKZ15_25285) | 51821..52219 | - | 399 | WP_001153665.1 | hypothetical protein | - |
| KKZ15_RS25405 (KKZ15_25290) | 52338..52775 | - | 438 | WP_000539665.1 | type IV pilus biogenesis protein PilM | - |
| KKZ15_RS25410 (KKZ15_25295) | 52781..54016 | - | 1236 | WP_015059538.1 | TcpQ domain-containing protein | - |
| KKZ15_RS25415 (KKZ15_25300) | 54019..54318 | - | 300 | WP_000835764.1 | TrbM/KikA/MpfK family conjugal transfer protein | - |
| KKZ15_RS25420 (KKZ15_25305) | 54386..54667 | - | 282 | WP_000638823.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KKZ15_RS25425 (KKZ15_25310) | 54657..54908 | - | 252 | WP_000121741.1 | hypothetical protein | Antitoxin |
| KKZ15_RS25430 (KKZ15_25315) | 55008..55643 | - | 636 | WP_015059536.1 | hypothetical protein | - |
| KKZ15_RS25435 (KKZ15_25320) | 55716..56003 | - | 288 | WP_001032611.1 | EexN family lipoprotein | - |
| KKZ15_RS25440 (KKZ15_25325) | 56016..56270 | - | 255 | WP_001043555.1 | EexN family lipoprotein | - |
| KKZ15_RS25445 (KKZ15_25330) | 56272..56913 | - | 642 | WP_001425343.1 | type IV secretion system protein | - |
| KKZ15_RS25450 (KKZ15_25335) | 56919..57914 | - | 996 | WP_001028543.1 | type IV secretion system protein | - |
| KKZ15_RS25455 (KKZ15_25340) | 57918..58175 | - | 258 | WP_000739144.1 | hypothetical protein | - |
| KKZ15_RS25460 (KKZ15_25345) | 58172..58474 | - | 303 | WP_001360345.1 | hypothetical protein | - |
| KKZ15_RS25465 (KKZ15_25350) | 58455..58712 | - | 258 | WP_001542015.1 | hypothetical protein | - |
| KKZ15_RS25470 (KKZ15_25355) | 58745..59191 | - | 447 | WP_001243165.1 | hypothetical protein | - |
| KKZ15_RS25475 (KKZ15_25360) | 59202..59372 | - | 171 | WP_000550720.1 | hypothetical protein | - |
| KKZ15_RS25480 (KKZ15_25365) | 59376..59819 | - | 444 | WP_000964330.1 | NfeD family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..63918 | 63918 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10945.79 Da Isoelectric Point: 10.4997
>T204308 WP_000638823.1 NZ_CP075719:c54667-54386 [Escherichia coli]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
Download Length: 282 bp
>T204308 NZ_CP100695:c4243681-4243373 [Salmonella enterica subsp. enterica serovar Weltevreden]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9223.38 Da Isoelectric Point: 3.9823
>AT204308 WP_000121741.1 NZ_CP075719:c54908-54657 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
Download Length: 252 bp
>AT204308 NZ_CP100695:c4243923-4243684 [Salmonella enterica subsp. enterica serovar Weltevreden]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|