Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 7032..7533 | Replicon | plasmid pCPWW7-IncI2 |
| Accession | NZ_CP075719 | ||
| Organism | Escherichia coli strain CPww7 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | H1ZXU8 |
| Locus tag | KKZ15_RS25170 | Protein ID | WP_000702247.1 |
| Coordinates | 7032..7292 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | KKZ15_RS25175 | Protein ID | WP_001132407.1 |
| Coordinates | 7282..7533 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KKZ15_RS25125 | 2570..2722 | + | 153 | Protein_2 | FlmC family protein | - |
| KKZ15_RS25130 (KKZ15_25015) | 2670..2789 | + | 120 | WP_228932012.1 | Hok/Gef family protein | - |
| KKZ15_RS25135 (KKZ15_25020) | 2939..3535 | + | 597 | WP_000125165.1 | ProQ/FINO family protein | - |
| KKZ15_RS25140 (KKZ15_25025) | 3553..3837 | - | 285 | WP_001162371.1 | hypothetical protein | - |
| KKZ15_RS25145 (KKZ15_25030) | 3911..4576 | - | 666 | WP_000532148.1 | division plane positioning ATPase MipZ | - |
| KKZ15_RS25150 (KKZ15_25035) | 5174..5503 | + | 330 | WP_000855120.1 | hypothetical protein | - |
| KKZ15_RS25155 (KKZ15_25040) | 6085..6408 | + | 324 | WP_000427403.1 | hypothetical protein | - |
| KKZ15_RS25160 (KKZ15_25045) | 6450..6659 | + | 210 | WP_000866036.1 | hypothetical protein | - |
| KKZ15_RS25165 (KKZ15_25050) | 6756..6980 | + | 225 | WP_000814381.1 | hypothetical protein | - |
| KKZ15_RS25170 (KKZ15_25055) | 7032..7292 | + | 261 | WP_000702247.1 | hypothetical protein | Toxin |
| KKZ15_RS25175 (KKZ15_25060) | 7282..7533 | + | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
| KKZ15_RS25180 (KKZ15_25065) | 8083..8361 | + | 279 | WP_000545938.1 | hypothetical protein | - |
| KKZ15_RS25185 (KKZ15_25070) | 8781..9047 | + | 267 | WP_000681608.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| KKZ15_RS25190 | 9154..9597 | - | 444 | WP_000068545.1 | hypothetical protein | - |
| KKZ15_RS25195 (KKZ15_25080) | 9894..10076 | + | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
| KKZ15_RS25200 (KKZ15_25085) | 10101..10538 | + | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| KKZ15_RS25205 (KKZ15_25090) | 10669..10995 | - | 327 | WP_063078684.1 | hypothetical protein | - |
| KKZ15_RS25210 (KKZ15_25095) | 11015..11722 | - | 708 | WP_021503228.1 | hypothetical protein | - |
| KKZ15_RS25215 (KKZ15_25100) | 11724..12476 | - | 753 | WP_000797966.1 | conjugal transfer protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..63918 | 63918 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9817.29 Da Isoelectric Point: 10.0665
>T204307 WP_000702247.1 NZ_CP075719:7032-7292 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T204307 NZ_CP100695:c4192914-4192627 [Salmonella enterica subsp. enterica serovar Weltevreden]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT204307 WP_001132407.1 NZ_CP075719:7282-7533 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT204307 NZ_CP100695:c4192640-4192338 [Salmonella enterica subsp. enterica serovar Weltevreden]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGTGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACGCAGGCCTCTGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAAGCGATGCTGCGAGAGCAAAATAAGAAATAG
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGTGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACGCAGGCCTCTGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAAGCGATGCTGCGAGAGCAAAATAAGAAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|