Detailed information of TA system TA020430

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1383766..1384454
• Replicon: chromosome
• Accession: NC_002755
• Organism: Mycobacterium tuberculosis CDC1551

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: MT_RS06565
• Protein ID: WP_003406304.1
• Coordinates: 1384023..1384454 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: MT_RS06560
• Protein ID: WP_003406302.1
• Coordinates: 1383766..1384026 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MT_RS06540	1379343..1380167	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
MT_RS06545	1380172..1381353	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
MT_RS06550	1381430..1382530	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
MT_RS06555	1382701..1383690	+	990	WP_003406301.1	malate dehydrogenase	-
MT_RS06560	1383766..1384026	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
MT_RS06565	1384023..1384454	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
MT_RS06570	1384477..1386165	-	1689	WP_003910308.1	PE family protein	-
MT_RS06575	1386345..1387205	+	861	WP_003900301.1	hypothetical protein	-
MT_RS06580	1387286..1388116	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
MT_RS06585	1388173..1388466	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
MT_RS06590	1388463..1388731	-	269	Protein_1288	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T20430 WP_003406304.1 NC_002755:1384023-1384454 [Mycobacterium tuberculosis CDC1551]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T20430 NC_002755:1384023-1384454 [Mycobacterium tuberculosis CDC1551]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGCG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT20430 WP_003406302.1 NC_002755:1383766-1384026 [Mycobacterium tuberculosis CDC1551]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT20430 NC_002755:1383766-1384026 [Mycobacterium tuberculosis CDC1551]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6