Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RelE-RHH |
| Location | 85419..85966 | Replicon | plasmid pCPWW7-IncF |
| Accession | NZ_CP075717 | ||
| Organism | Escherichia coli strain CPww7 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G7QEJ9 |
| Locus tag | KKZ15_RS24140 | Protein ID | WP_001384452.1 |
| Coordinates | 85419..85697 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A2H4TKU7 |
| Locus tag | KKZ15_RS24145 | Protein ID | WP_000079923.1 |
| Coordinates | 85697..85966 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KKZ15_RS24110 (81337) | 81337..81645 | - | 309 | Protein_79 | integrase core domain-containing protein | - |
| KKZ15_RS24115 (81662) | 81662..82738 | - | 1077 | WP_000227970.1 | IS110 family transposase | - |
| KKZ15_RS24120 (83020) | 83020..83616 | - | 597 | Protein_81 | IS3 family transposase | - |
| KKZ15_RS24125 (83625) | 83625..84776 | - | 1152 | WP_195686664.1 | IS30-like element IS30 family transposase | - |
| KKZ15_RS24130 (84844) | 84844..85146 | - | 303 | Protein_83 | transposase | - |
| KKZ15_RS24135 (85182) | 85182..85379 | - | 198 | Protein_84 | 3'-5' exonuclease | - |
| KKZ15_RS24140 (85419) | 85419..85697 | - | 279 | WP_001384452.1 | type II toxin-antitoxin system toxin YacB | Toxin |
| KKZ15_RS24145 (85697) | 85697..85966 | - | 270 | WP_000079923.1 | type II toxin-antitoxin system antitoxin YacA | Antitoxin |
| KKZ15_RS24150 (86873) | 86873..87729 | - | 857 | Protein_87 | incFII family plasmid replication initiator RepA | - |
| KKZ15_RS24155 (87722) | 87722..87796 | - | 75 | WP_001365705.1 | RepA leader peptide Tap | - |
| KKZ15_RS24160 (87845) | 87845..87970 | + | 126 | WP_001436741.1 | hypothetical protein | - |
| KKZ15_RS24165 (88043) | 88043..88291 | - | 249 | WP_000083838.1 | replication regulatory protein RepA | - |
| KKZ15_RS24170 (88575) | 88575..88724 | - | 150 | WP_074152653.1 | Hok/Gef family protein | - |
| - (88768) | 88768..88829 | + | 62 | NuclAT_1 | - | - |
| - (88768) | 88768..88829 | + | 62 | NuclAT_1 | - | - |
| - (88768) | 88768..88829 | + | 62 | NuclAT_1 | - | - |
| - (88768) | 88768..88829 | + | 62 | NuclAT_1 | - | - |
| KKZ15_RS24175 (89088) | 89088..89387 | - | 300 | WP_050593763.1 | hypothetical protein | - |
| KKZ15_RS24180 (89505) | 89505..89951 | - | 447 | WP_063115548.1 | thermonuclease family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..162438 | 162438 | |
| - | inside | IScluster/Tn | - | - | 81337..92505 | 11168 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10762.38 Da Isoelectric Point: 8.4615
>T204297 WP_001384452.1 NZ_CP075717:c85697-85419 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP
Download Length: 279 bp
>T204297 NZ_CP100693:c4226421-4225930 [Salmonella enterica subsp. enterica serovar London]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAAGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAAGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10196.52 Da Isoelectric Point: 7.2050
>AT204297 WP_000079923.1 NZ_CP075717:c85966-85697 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVEQQHNTWFRDQVAAGRQQLERGDVLPHDMVESSATAWRD
EMSRKVAGK
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVEQQHNTWFRDQVAAGRQQLERGDVLPHDMVESSATAWRD
EMSRKVAGK
Download Length: 270 bp
>AT204297 NZ_CP100693:c4226711-4226418 [Salmonella enterica subsp. enterica serovar London]
ATGTCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCACAGGCTTATCAGGAATTTCTCGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCACCGTGGGAGCAGGAAAAATGA
ATGTCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCACAGGCTTATCAGGAATTTCTCGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCACCGTGGGAGCAGGAAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CL36 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2H4TKU7 |