Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2427959..2428757 Replicon chromosome
Accession NZ_CP075716
Organism Escherichia coli strain CPww7

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1X1M0U2
Locus tag KKZ15_RS11925 Protein ID WP_000854919.1
Coordinates 2427959..2428336 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2G4AEZ5
Locus tag KKZ15_RS11930 Protein ID WP_001285608.1
Coordinates 2428383..2428757 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKZ15_RS11885 (2423019) 2423019..2423735 + 717 WP_001295734.1 N-acetylneuraminic acid outer membrane channel NanC -
KKZ15_RS11890 (2423755) 2423755..2424861 + 1107 WP_001044128.1 N-acetylneuraminate epimerase -
KKZ15_RS11895 (2424926) 2424926..2425906 + 981 WP_000379695.1 sialate O-acetylesterase -
KKZ15_RS11900 (2425914) 2425914..2426018 - 105 Protein_2331 HNH endonuclease -
KKZ15_RS11905 (2426118) 2426118..2426261 + 144 Protein_2332 HNH endonuclease -
KKZ15_RS11910 (2427071) 2427071..2427172 - 102 Protein_2333 hypothetical protein -
KKZ15_RS11915 (2427257) 2427257..2427454 - 198 WP_001327226.1 DUF957 domain-containing protein -
KKZ15_RS11920 (2427474) 2427474..2427962 - 489 WP_000777664.1 DUF5983 family protein -
KKZ15_RS11925 (2427959) 2427959..2428336 - 378 WP_000854919.1 TA system toxin CbtA family protein Toxin
KKZ15_RS11930 (2428383) 2428383..2428757 - 375 WP_001285608.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
KKZ15_RS11935 (2428837) 2428837..2429058 - 222 WP_112021664.1 DUF987 domain-containing protein -
KKZ15_RS11940 (2429145) 2429145..2429621 - 477 WP_001560293.1 RadC family protein -
KKZ15_RS11945 (2429636) 2429636..2430115 - 480 WP_000706980.1 antirestriction protein -
KKZ15_RS11950 (2430381) 2430381..2431199 - 819 WP_001175165.1 DUF932 domain-containing protein -
KKZ15_RS11955 (2431289) 2431289..2431522 - 234 WP_001278293.1 DUF905 family protein -
KKZ15_RS11960 (2431528) 2431528..2432205 - 678 WP_001097301.1 hypothetical protein -
KKZ15_RS11965 (2432353) 2432353..2433033 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE / fimB / papC / papD 2418139..2456571 38432


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14037.97 Da        Isoelectric Point: 7.9086

>T204288 WP_000854919.1 NZ_CP075716:c2428336-2427959 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

>T204288 NZ_CP100693:329752-330120 [Salmonella enterica subsp. enterica serovar London]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13610.37 Da        Isoelectric Point: 5.5051

>AT204288 WP_001285608.1 NZ_CP075716:c2428757-2428383 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPAITS

Download         Length: 375 bp

>AT204288 NZ_CP100693:329534-329755 [Salmonella enterica subsp. enterica serovar London]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACACGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAATTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1M0U2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4AEZ5

References