Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1230207..1230754 Replicon chromosome
Accession NC_002755
Organism Mycobacterium tuberculosis CDC1551

Toxin (Protein)


Gene name mazF Uniprot ID P9WIH8
Locus tag MT_RS05840 Protein ID WP_003898728.1
Coordinates 1230207..1230518 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q8VK70
Locus tag MT_RS05845 Protein ID WP_003913656.1
Coordinates 1230518..1230754 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT_RS05820 1225688..1227112 - 1425 WP_003405805.1 class II fumarate hydratase -
MT_RS05825 1227143..1228231 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
MT_RS05830 1228287..1228931 + 645 WP_003915494.1 DUF4245 domain-containing protein -
MT_RS05835 1228938..1230095 - 1158 WP_003898727.1 AI-2E family transporter -
MT_RS05840 1230207..1230518 - 312 WP_003898728.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
MT_RS05845 1230518..1230754 - 237 WP_003913656.1 hypothetical protein Antitoxin
MT_RS20950 1230849..1232374 + 1526 Protein_1145 carboxylesterase/lipase family protein -
MT_RS05860 1232392..1233504 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
MT_RS05865 1233514..1233771 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
MT_RS05870 1233761..1235008 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
MT_RS05875 1235005..1235643 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11049.76 Da        Isoelectric Point: 4.9371

>T20428 WP_003898728.1 NC_002755:c1230518-1230207 [Mycobacterium tuberculosis CDC1551]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNTQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T20428 NC_002755:c1230518-1230207 [Mycobacterium tuberculosis CDC1551]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACACCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8608.66 Da        Isoelectric Point: 5.6908

>AT20428 WP_003913656.1 NC_002755:c1230754-1230518 [Mycobacterium tuberculosis CDC1551]
VSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEILATNTSATGDLDTLAGHCARTALDID

Download         Length: 237 bp

>AT20428 NC_002755:c1230754-1230518 [Mycobacterium tuberculosis CDC1551]
GTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATGCCCG
TAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATCCTCG
CCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CCA
PDB 5UCT

Antitoxin

Source ID Structure
AlphaFold DB Q8VK70

References