Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 8368..8869 | Replicon | plasmid pSTEC2018_607-d |
| Accession | NZ_CP075701 | ||
| Organism | Escherichia coli strain STEC2018-607 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | A0A6X6XTU7 |
| Locus tag | JFX52_RS27095 | Protein ID | WP_000702245.1 |
| Coordinates | 8368..8628 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | JFX52_RS27100 | Protein ID | WP_001132407.1 |
| Coordinates | 8618..8869 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JFX52_RS28470 | 3907..4059 | + | 153 | Protein_2 | DUF5431 family protein | - |
| JFX52_RS27055 (JFX52_27055) | 4004..4126 | + | 123 | WP_223685802.1 | Hok/Gef family protein | - |
| JFX52_RS27060 (JFX52_27060) | 4276..4872 | + | 597 | WP_000125165.1 | ProQ/FINO family protein | - |
| JFX52_RS27065 (JFX52_27065) | 4890..5174 | - | 285 | WP_001162371.1 | hypothetical protein | - |
| JFX52_RS27070 (JFX52_27070) | 5248..5913 | - | 666 | WP_000532148.1 | division plane positioning ATPase MipZ | - |
| JFX52_RS27075 (JFX52_27075) | 6511..6840 | + | 330 | WP_000855121.1 | hypothetical protein | - |
| JFX52_RS27080 (JFX52_27080) | 7421..7744 | + | 324 | WP_000427402.1 | hypothetical protein | - |
| JFX52_RS27085 (JFX52_27085) | 7785..7994 | + | 210 | WP_000866037.1 | hypothetical protein | - |
| JFX52_RS27090 (JFX52_27090) | 8092..8316 | + | 225 | WP_000814383.1 | hypothetical protein | - |
| JFX52_RS27095 (JFX52_27095) | 8368..8628 | + | 261 | WP_000702245.1 | hypothetical protein | Toxin |
| JFX52_RS27100 (JFX52_27100) | 8618..8869 | + | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
| JFX52_RS27105 (JFX52_27105) | 9419..9697 | + | 279 | WP_000545937.1 | hypothetical protein | - |
| JFX52_RS28475 | 10085..10528 | - | 444 | WP_000192626.1 | hypothetical protein | - |
| JFX52_RS27115 (JFX52_27115) | 10825..11007 | + | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
| JFX52_RS27120 (JFX52_27120) | 11032..11469 | + | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| JFX52_RS27125 (JFX52_27125) | 11600..11920 | - | 321 | WP_001310435.1 | hypothetical protein | - |
| JFX52_RS27130 (JFX52_27130) | 12254..12432 | - | 179 | Protein_18 | hypothetical protein | - |
| JFX52_RS28480 | 12767..12886 | - | 120 | Protein_19 | hypothetical protein | - |
| JFX52_RS27140 (JFX52_27140) | 12906..13505 | - | 600 | WP_000091423.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | - | 1..59820 | 59820 | |
| - | flank | IS/Tn | - | - | 2298..3446 | 1148 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9818.23 Da Isoelectric Point: 9.5163
>T204273 WP_000702245.1 NZ_CP075701:8368-8628 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEEAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEEAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T204273 NZ_CP100689:4559268-4559579 [Salmonella enterica subsp. enterica serovar Newport]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT204273 WP_001132407.1 NZ_CP075701:8618-8869 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT204273 NZ_CP100689:4559576-4560022 [Salmonella enterica subsp. enterica serovar Newport]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|