Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2702826..2703660 Replicon chromosome
Accession NZ_CP075697
Organism Escherichia coli strain STEC2018-607

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag JFX52_RS13070 Protein ID WP_001518317.1
Coordinates 2702826..2703203 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag JFX52_RS13075 Protein ID WP_032330759.1
Coordinates 2703292..2703660 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFX52_RS13045 (2698192) 2698192..2699115 - 924 WP_000535960.1 carboxylate/amino acid/amine transporter -
JFX52_RS13050 (2699226) 2699226..2700410 - 1185 WP_001172876.1 sugar efflux transporter -
JFX52_RS28205 (2700807) 2700807..2700968 - 162 Protein_2564 RhuM family protein -
JFX52_RS13055 (2701202) 2701202..2702047 - 846 WP_001518322.1 DUF4942 domain-containing protein -
JFX52_RS13060 (2702132) 2702132..2702329 - 198 WP_000839251.1 DUF957 domain-containing protein -
JFX52_RS13065 (2702341) 2702341..2702829 - 489 WP_032330753.1 DUF5983 family protein -
JFX52_RS13070 (2702826) 2702826..2703203 - 378 WP_001518317.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
JFX52_RS13075 (2703292) 2703292..2703660 - 369 WP_032330759.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
JFX52_RS13080 (2703739) 2703739..2703960 - 222 WP_000692312.1 DUF987 domain-containing protein -
JFX52_RS13085 (2704029) 2704029..2704505 - 477 WP_001518017.1 RadC family protein -
JFX52_RS13090 (2704521) 2704521..2704994 - 474 WP_032330754.1 antirestriction protein -
JFX52_RS13095 (2705088) 2705088..2705333 - 246 WP_001518015.1 hypothetical protein -
JFX52_RS13100 (2705333) 2705333..2706154 - 822 WP_032330755.1 DUF932 domain-containing protein -
JFX52_RS28210 (2706333) 2706333..2706422 - 90 WP_112031555.1 DUF905 family protein -
JFX52_RS13110 (2706565) 2706565..2707020 - 456 WP_033804098.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13964.02 Da        Isoelectric Point: 8.9341

>T204246 WP_001518317.1 NZ_CP075697:c2703203-2702826 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKYPEAKR

Download         Length: 378 bp

>T204246 NZ_CP100682:3496351-3496596 [Salmonella enterica subsp. enterica serovar Goldcoast]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCGG
CGACTGCCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCGGACGGGTGTATTGTGCTAATGG
CGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTATCAGGCTGAACAGGTAGTTAAGGGGATGTGGGACGTGATT
GTTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13603.35 Da        Isoelectric Point: 5.8746

>AT204246 WP_032330759.1 NZ_CP075697:c2703660-2703292 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT204246 NZ_CP100682:c3496560-3496204 [Salmonella enterica subsp. enterica serovar Goldcoast]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References